Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens
In the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nNOS) in the rat nucleus accumbens (NAc) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the NAc in central fatigue. In the experiment, adul...
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| Veröffentlicht in: | Scandinavian journal of medicine & science in sports 2008-12, Vol.18 (6), p.715-718 |
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| creator | Liu, H.-Y. Jin, J. Tang, J.-S. Cui, J.-M. |
| description | In the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nNOS) in the rat nucleus accumbens (NAc) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the NAc in central fatigue. In the experiment, adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks. Immunohistochemistry was used for measurement of the nNOS‐positive neurons associated with the image manipulation. Our results showed that a long‐time exposure to chronic forced swim stress increased the number of nNOS immunoreactive‐positive neurons in the rat NAc (106.7%, P |
| doi_str_mv | 10.1111/j.1600-0838.2007.00722.x |
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In the experiment, adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks. Immunohistochemistry was used for measurement of the nNOS‐positive neurons associated with the image manipulation. Our results showed that a long‐time exposure to chronic forced swim stress increased the number of nNOS immunoreactive‐positive neurons in the rat NAc (106.7%, P<0.001), distributed area (150.2%, P<0.001) and gray degree value (11.3%, P<0.01). The results indicate that nitric oxide (NO)/nNOS may be involved in the formation of the fatigue stress, and that NO may play a role in the regulation of stress in the NAc. The up‐regulation of NO/nNOS during the exposure to long‐time swim stress is likely to be one of the results of brain damage and psychiatric disorder induced by NO overproduction.</description><identifier>ISSN: 0905-7188</identifier><identifier>EISSN: 1600-0838</identifier><identifier>DOI: 10.1111/j.1600-0838.2007.00722.x</identifier><identifier>PMID: 18248551</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anatomy & physiology ; Animals ; Brain research ; Chronic Disease ; Chronic fatigue syndrome ; Enzymes ; exercise neurobiology ; Fatigue - enzymology ; Fatigue - physiopathology ; fatigue stress ; immunohistochemistry ; neuronal nitric oxide synthase (nNOS) ; Neurons ; Nitric oxide ; Nitric Oxide Synthase - metabolism ; nucleus accumbens (NAc) ; Nucleus Accumbens - enzymology ; Physical Conditioning, Animal ; Physical Exertion ; Rats ; Rats, Wistar ; Rodents ; swim ; Up-Regulation - physiology</subject><ispartof>Scandinavian journal of medicine & science in sports, 2008-12, Vol.18 (6), p.715-718</ispartof><rights>Copyright © 2008 The Authors. Journal compilation © 2007 Blackwell Munksgard</rights><rights>Journal compilation © 2008 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4622-653de7895956bac293546a020d0375f11dc664f6152bca8d350da53828a8cee63</citedby><cites>FETCH-LOGICAL-c4622-653de7895956bac293546a020d0375f11dc664f6152bca8d350da53828a8cee63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0838.2007.00722.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0838.2007.00722.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18248551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, H.-Y.</creatorcontrib><creatorcontrib>Jin, J.</creatorcontrib><creatorcontrib>Tang, J.-S.</creatorcontrib><creatorcontrib>Cui, J.-M.</creatorcontrib><title>Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens</title><title>Scandinavian journal of medicine & science in sports</title><addtitle>Scand J Med Sci Sports</addtitle><description>In the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nNOS) in the rat nucleus accumbens (NAc) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the NAc in central fatigue. In the experiment, adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks. Immunohistochemistry was used for measurement of the nNOS‐positive neurons associated with the image manipulation. Our results showed that a long‐time exposure to chronic forced swim stress increased the number of nNOS immunoreactive‐positive neurons in the rat NAc (106.7%, P<0.001), distributed area (150.2%, P<0.001) and gray degree value (11.3%, P<0.01). The results indicate that nitric oxide (NO)/nNOS may be involved in the formation of the fatigue stress, and that NO may play a role in the regulation of stress in the NAc. The up‐regulation of NO/nNOS during the exposure to long‐time swim stress is likely to be one of the results of brain damage and psychiatric disorder induced by NO overproduction.</description><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Brain research</subject><subject>Chronic Disease</subject><subject>Chronic fatigue syndrome</subject><subject>Enzymes</subject><subject>exercise neurobiology</subject><subject>Fatigue - enzymology</subject><subject>Fatigue - physiopathology</subject><subject>fatigue stress</subject><subject>immunohistochemistry</subject><subject>neuronal nitric oxide synthase (nNOS)</subject><subject>Neurons</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>nucleus accumbens (NAc)</subject><subject>Nucleus Accumbens - enzymology</subject><subject>Physical Conditioning, Animal</subject><subject>Physical Exertion</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>swim</subject><subject>Up-Regulation - physiology</subject><issn>0905-7188</issn><issn>1600-0838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV2PEyEUhonRuN3Vv2CIF97NCMzAMIk32uium_qRVLOXhDJnttQpVBhi---X2TZr4o1LQiA5z3ty4EEIU1LSvN5uSioIKYisZMkIacq8GSv3T9DsofAUzUhLeNFQKc_QeYwbQmjT1vw5OqOS1ZJzOkNmvg7eWYN7PdrbBDiOAWLEA-gu4tHjtCsC3KYhl73DvsfOjiHzfm-7TB_cuNYRsHV4XAMOesQumQFSxNqYtF2Biy_Qs14PEV6ezgv089PHH_OrYvHt8vP8_aIwtWCsELzqoJEtb7lYacPaitdCE0Y6UjW8p7QzQtS9oJytjJZdxUmneSWZ1NIAiOoCvTn23QX_O0Ec1dZGA8OgHfgUlWhlQwXn_wVpnqCpqczg63_AjU_B5UcoRmvCiRATJI-QCT7GAL3aBbvV4aAoUZMutVGTFTVZUZMuda9L7XP01al_Wm2h-xs8-cnAuyPwxw5weHRjtfyyzJccL45xG0fYP8R1-KVEkz9V3Xy9VNc31Xz5YbFU36s7vVCx3Q</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Liu, H.-Y.</creator><creator>Jin, J.</creator><creator>Tang, J.-S.</creator><creator>Cui, J.-M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens</title><author>Liu, H.-Y. ; Jin, J. ; Tang, J.-S. ; Cui, J.-M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4622-653de7895956bac293546a020d0375f11dc664f6152bca8d350da53828a8cee63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Brain research</topic><topic>Chronic Disease</topic><topic>Chronic fatigue syndrome</topic><topic>Enzymes</topic><topic>exercise neurobiology</topic><topic>Fatigue - enzymology</topic><topic>Fatigue - physiopathology</topic><topic>fatigue stress</topic><topic>immunohistochemistry</topic><topic>neuronal nitric oxide synthase (nNOS)</topic><topic>Neurons</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>nucleus accumbens (NAc)</topic><topic>Nucleus Accumbens - enzymology</topic><topic>Physical Conditioning, Animal</topic><topic>Physical Exertion</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>swim</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, H.-Y.</creatorcontrib><creatorcontrib>Jin, J.</creatorcontrib><creatorcontrib>Tang, J.-S.</creatorcontrib><creatorcontrib>Cui, J.-M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of medicine & science in sports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, H.-Y.</au><au>Jin, J.</au><au>Tang, J.-S.</au><au>Cui, J.-M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens</atitle><jtitle>Scandinavian journal of medicine & science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2008-12</date><risdate>2008</risdate><volume>18</volume><issue>6</issue><spage>715</spage><epage>718</epage><pages>715-718</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract>In the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nNOS) in the rat nucleus accumbens (NAc) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the NAc in central fatigue. In the experiment, adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks. Immunohistochemistry was used for measurement of the nNOS‐positive neurons associated with the image manipulation. Our results showed that a long‐time exposure to chronic forced swim stress increased the number of nNOS immunoreactive‐positive neurons in the rat NAc (106.7%, P<0.001), distributed area (150.2%, P<0.001) and gray degree value (11.3%, P<0.01). The results indicate that nitric oxide (NO)/nNOS may be involved in the formation of the fatigue stress, and that NO may play a role in the regulation of stress in the NAc. The up‐regulation of NO/nNOS during the exposure to long‐time swim stress is likely to be one of the results of brain damage and psychiatric disorder induced by NO overproduction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18248551</pmid><doi>10.1111/j.1600-0838.2007.00722.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Anatomy & physiology Animals Brain research Chronic Disease Chronic fatigue syndrome Enzymes exercise neurobiology Fatigue - enzymology Fatigue - physiopathology fatigue stress immunohistochemistry neuronal nitric oxide synthase (nNOS) Neurons Nitric oxide Nitric Oxide Synthase - metabolism nucleus accumbens (NAc) Nucleus Accumbens - enzymology Physical Conditioning, Animal Physical Exertion Rats Rats, Wistar Rodents swim Up-Regulation - physiology |
| title | Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens |
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