Polyaspartoyl l-arginine protects endothelial cells against injury

Polyaspartoyl l-arginine (PDR) is an anti-thrombotic agent and its anti-thrombotic effect is related with endothelial cells. This study is to investigate the effect of PDR on the endothelial cells. In cell injury assay 1.7–170 µg/ml of PDR significantly increased the viability of rat aorta endotheli...

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Veröffentlicht in:	European journal of pharmacology 2008-12, Vol.599 (1), p.96-101
Hauptverfasser:	Jian, Yang, Tang, Zhiyu, Wang, Yinye, Peng, Shiqi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - pharmacology Animals Antioxidants - administration & dosage Antioxidants - pharmacology Aorta, Abdominal - cytology Aorta, Abdominal - drug effects Apoptosis Apoptosis - drug effects Arginine - pharmacology Biological and medical sciences Cell Survival - drug effects Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - pharmacology Hydrogen Peroxide l-arginine Lipoproteins, LDL Male Medical sciences Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Oxidative injury Oxidative Stress - drug effects Peptides - administration & dosage Peptides - pharmacology Pharmacology. Drug treatments Polyaspartoyl l-arginine Rat aorta endothelial cell Rats Rats, Sprague-Dawley
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