Overexpression of the wild type p73 gene in breast cancer tissues and cell lines

The p73 gene is a structural and, in overexpression systems, functional p53 homologue. Ectopic p73 expression can activate a broad subset of p53-responsive genes, induce apoptosis, and act as a growth suppressor. Yet, viral oncoproteins that antagonize p53 (adenovirus E1B 55K, SV40 large T, and huma...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-07, Vol.59 (13), p.3257-3263
Hauptverfasser:	ZAIKA, A. I, KOVALEV, S, MARCHENKO, N. D, MOLL, U. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Exons Female Gene Expression Genes, p53 Genes, Tumor Suppressor Genetic Variation Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Molecular Sequence Data Neoplasm Invasiveness Nuclear Proteins - chemistry Nuclear Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Tumor Cells, Cultured Tumor Protein p73 Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Proteins Tumors
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