IN VITRO ACTIVITIES OF 28 ANTIMICROBIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) FROM A CLINICAL SETTING IN MALAYSIA
Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA...
Gespeichert in:
| Veröffentlicht in: | Southeast Asian journal of tropical medicine and public health 2008-09, Vol.39 (5), p.885-892 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 892 |
|---|---|
| container_issue | 5 |
| container_start_page | 885 |
| container_title | Southeast Asian journal of tropical medicine and public health |
| container_volume | 39 |
| creator | NEELA, V SASIKUMAR, M GHAZNAVI, G. R ZAMBERI, S MARIANA, S |
| description | Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA isolates to various classes of antibiotics and to identify the most potent antibiotics, thirty-two clinical isolates comprised of hospital acquired (HA) and community acquired (CA) infections were investigated by disk diffusion test. Of the 32 MRSA isolates, 14 (43.75%) and 18 (56.25%) were community and hospital acquired MRSA, respectively. All isolates were multiple drug resistant to more than 3 classes of antibiotics despite the source or specimen from which it was isolated. The oxacillin MICs for all isolates ranged from 2 to > or = 256 microg/ml. Twenty-five of 26 erythromycin-resistant MRSA isolates exhibited an inducible MLS(B) resistance phenotype while one showed an MS phenotype. More than half the isolates (68.75%) were resistant to at least one of the six aminoglycosides tested, with netilmicin as the most susceptible. The most effective antistaphylococcal agents were linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin exhibited 100% susceptibility. Since MRSA is under continuous pressure of acquiring multiple drug resistance, it is imperative to focus routine surveillance on HA and CA-MRSA strains to monitor and limit the spread of this organism. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69870057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69870057</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1115-8e070b0d14336324915cd70e27528f6d6a12a77feaa6eff9c79ce26333d02b443</originalsourceid><addsrcrecordid>eNpd0N1KwzAUB_BeKG5OX0GCoOhFIUmbpLmModsC_ZA2E3ZVsjaFSfdhay98CN_ZiNMLScj_XPzO4ZAzbwoRJj4iFE-8y2F4hTCEiEcX3gRxSCJ3pt6nysCL0kUOhNTKVSouQT4HOAIi0ypVssiflEiAWMSZLl0IlZUapLFeKqmSRGV-EZeq1I4D9z4v10kucylXDq-K2MVDWpTiEcyLPAUCSNeipJtYxlqrbAHcBqlIxLpU4so7b0032OtTzrzVPNZy6Sf54rvHPyKEiB9ZyOAGNigMAhrgkCNSNwxazAiOWtpQg7BhrLXGUNu2vGa8tpgGQdBAvAnDYObd_8w99oe30Q7v1W471LbrzN4exqGiPGIQEubg7T_4ehj7vdutwhCFlHHCHbo5oXGzs0117Lc7039Uv7_swN0JmKE2Xdubfb0d_hyGNHSXB19Tq3eL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201467959</pqid></control><display><type>article</type><title>IN VITRO ACTIVITIES OF 28 ANTIMICROBIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) FROM A CLINICAL SETTING IN MALAYSIA</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>NEELA, V ; SASIKUMAR, M ; GHAZNAVI, G. R ; ZAMBERI, S ; MARIANA, S</creator><creatorcontrib>NEELA, V ; SASIKUMAR, M ; GHAZNAVI, G. R ; ZAMBERI, S ; MARIANA, S</creatorcontrib><description>Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA isolates to various classes of antibiotics and to identify the most potent antibiotics, thirty-two clinical isolates comprised of hospital acquired (HA) and community acquired (CA) infections were investigated by disk diffusion test. Of the 32 MRSA isolates, 14 (43.75%) and 18 (56.25%) were community and hospital acquired MRSA, respectively. All isolates were multiple drug resistant to more than 3 classes of antibiotics despite the source or specimen from which it was isolated. The oxacillin MICs for all isolates ranged from 2 to > or = 256 microg/ml. Twenty-five of 26 erythromycin-resistant MRSA isolates exhibited an inducible MLS(B) resistance phenotype while one showed an MS phenotype. More than half the isolates (68.75%) were resistant to at least one of the six aminoglycosides tested, with netilmicin as the most susceptible. The most effective antistaphylococcal agents were linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin exhibited 100% susceptibility. Since MRSA is under continuous pressure of acquiring multiple drug resistance, it is imperative to focus routine surveillance on HA and CA-MRSA strains to monitor and limit the spread of this organism.</description><identifier>ISSN: 0125-1562</identifier><identifier>PMID: 19058585</identifier><identifier>CODEN: SJTMAK</identifier><language>eng</language><publisher>Bangkok: Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</publisher><subject>Anti-Bacterial Agents - pharmacology ; Bacterial diseases ; Biological and medical sciences ; Community-Acquired Infections - microbiology ; Cross Infection - microbiology ; Disk Diffusion Antimicrobial Tests ; Drug Resistance, Multiple, Bacterial ; General aspects ; Human bacterial diseases ; Humans ; Infectious diseases ; Malaysia ; Medical sciences ; Methicillin Resistance ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification</subject><ispartof>Southeast Asian journal of tropical medicine and public health, 2008-09, Vol.39 (5), p.885-892</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright Central Coordinating Board, SEAMEO-TROPMED Project Sep 2008</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20640649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19058585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NEELA, V</creatorcontrib><creatorcontrib>SASIKUMAR, M</creatorcontrib><creatorcontrib>GHAZNAVI, G. R</creatorcontrib><creatorcontrib>ZAMBERI, S</creatorcontrib><creatorcontrib>MARIANA, S</creatorcontrib><title>IN VITRO ACTIVITIES OF 28 ANTIMICROBIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) FROM A CLINICAL SETTING IN MALAYSIA</title><title>Southeast Asian journal of tropical medicine and public health</title><addtitle>Southeast Asian J Trop Med Public Health</addtitle><description>Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA isolates to various classes of antibiotics and to identify the most potent antibiotics, thirty-two clinical isolates comprised of hospital acquired (HA) and community acquired (CA) infections were investigated by disk diffusion test. Of the 32 MRSA isolates, 14 (43.75%) and 18 (56.25%) were community and hospital acquired MRSA, respectively. All isolates were multiple drug resistant to more than 3 classes of antibiotics despite the source or specimen from which it was isolated. The oxacillin MICs for all isolates ranged from 2 to > or = 256 microg/ml. Twenty-five of 26 erythromycin-resistant MRSA isolates exhibited an inducible MLS(B) resistance phenotype while one showed an MS phenotype. More than half the isolates (68.75%) were resistant to at least one of the six aminoglycosides tested, with netilmicin as the most susceptible. The most effective antistaphylococcal agents were linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin exhibited 100% susceptibility. Since MRSA is under continuous pressure of acquiring multiple drug resistance, it is imperative to focus routine surveillance on HA and CA-MRSA strains to monitor and limit the spread of this organism.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Cross Infection - microbiology</subject><subject>Disk Diffusion Antimicrobial Tests</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaysia</subject><subject>Medical sciences</subject><subject>Methicillin Resistance</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - isolation & purification</subject><issn>0125-1562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0N1KwzAUB_BeKG5OX0GCoOhFIUmbpLmModsC_ZA2E3ZVsjaFSfdhay98CN_ZiNMLScj_XPzO4ZAzbwoRJj4iFE-8y2F4hTCEiEcX3gRxSCJ3pt6nysCL0kUOhNTKVSouQT4HOAIi0ypVssiflEiAWMSZLl0IlZUapLFeKqmSRGV-EZeq1I4D9z4v10kucylXDq-K2MVDWpTiEcyLPAUCSNeipJtYxlqrbAHcBqlIxLpU4so7b0032OtTzrzVPNZy6Sf54rvHPyKEiB9ZyOAGNigMAhrgkCNSNwxazAiOWtpQg7BhrLXGUNu2vGa8tpgGQdBAvAnDYObd_8w99oe30Q7v1W471LbrzN4exqGiPGIQEubg7T_4ehj7vdutwhCFlHHCHbo5oXGzs0117Lc7039Uv7_swN0JmKE2Xdubfb0d_hyGNHSXB19Tq3eL</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>NEELA, V</creator><creator>SASIKUMAR, M</creator><creator>GHAZNAVI, G. R</creator><creator>ZAMBERI, S</creator><creator>MARIANA, S</creator><general>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</general><general>Central Coordinating Board, SEAMEO-TROPMED Project</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>IN VITRO ACTIVITIES OF 28 ANTIMICROBIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) FROM A CLINICAL SETTING IN MALAYSIA</title><author>NEELA, V ; SASIKUMAR, M ; GHAZNAVI, G. R ; ZAMBERI, S ; MARIANA, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1115-8e070b0d14336324915cd70e27528f6d6a12a77feaa6eff9c79ce26333d02b443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Cross Infection - microbiology</topic><topic>Disk Diffusion Antimicrobial Tests</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaysia</topic><topic>Medical sciences</topic><topic>Methicillin Resistance</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - isolation & purification</topic><toplevel>online_resources</toplevel><creatorcontrib>NEELA, V</creatorcontrib><creatorcontrib>SASIKUMAR, M</creatorcontrib><creatorcontrib>GHAZNAVI, G. R</creatorcontrib><creatorcontrib>ZAMBERI, S</creatorcontrib><creatorcontrib>MARIANA, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East & South Asia Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NEELA, V</au><au>SASIKUMAR, M</au><au>GHAZNAVI, G. R</au><au>ZAMBERI, S</au><au>MARIANA, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IN VITRO ACTIVITIES OF 28 ANTIMICROBIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) FROM A CLINICAL SETTING IN MALAYSIA</atitle><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle><addtitle>Southeast Asian J Trop Med Public Health</addtitle><date>2008-09</date><risdate>2008</risdate><volume>39</volume><issue>5</issue><spage>885</spage><epage>892</epage><pages>885-892</pages><issn>0125-1562</issn><coden>SJTMAK</coden><abstract>Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA isolates to various classes of antibiotics and to identify the most potent antibiotics, thirty-two clinical isolates comprised of hospital acquired (HA) and community acquired (CA) infections were investigated by disk diffusion test. Of the 32 MRSA isolates, 14 (43.75%) and 18 (56.25%) were community and hospital acquired MRSA, respectively. All isolates were multiple drug resistant to more than 3 classes of antibiotics despite the source or specimen from which it was isolated. The oxacillin MICs for all isolates ranged from 2 to > or = 256 microg/ml. Twenty-five of 26 erythromycin-resistant MRSA isolates exhibited an inducible MLS(B) resistance phenotype while one showed an MS phenotype. More than half the isolates (68.75%) were resistant to at least one of the six aminoglycosides tested, with netilmicin as the most susceptible. The most effective antistaphylococcal agents were linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin exhibited 100% susceptibility. Since MRSA is under continuous pressure of acquiring multiple drug resistance, it is imperative to focus routine surveillance on HA and CA-MRSA strains to monitor and limit the spread of this organism.</abstract><cop>Bangkok</cop><pub>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</pub><pmid>19058585</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0125-1562 |
| ispartof | Southeast Asian journal of tropical medicine and public health, 2008-09, Vol.39 (5), p.885-892 |
| issn | 0125-1562 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69870057 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents - pharmacology Bacterial diseases Biological and medical sciences Community-Acquired Infections - microbiology Cross Infection - microbiology Disk Diffusion Antimicrobial Tests Drug Resistance, Multiple, Bacterial General aspects Human bacterial diseases Humans Infectious diseases Malaysia Medical sciences Methicillin Resistance Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification |
| title | IN VITRO ACTIVITIES OF 28 ANTIMICROBIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) FROM A CLINICAL SETTING IN MALAYSIA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A25%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IN%20VITRO%20ACTIVITIES%20OF%2028%20ANTIMICROBIAL%20AGENTS%20AGAINST%20METHICILLIN-RESISTANT%20STAPHYLOCOCCUS%20AUREUS%20(MRSA)%20FROM%20A%20CLINICAL%20SETTING%20IN%20MALAYSIA&rft.jtitle=Southeast%20Asian%20journal%20of%20tropical%20medicine%20and%20public%20health&rft.au=NEELA,%20V&rft.date=2008-09&rft.volume=39&rft.issue=5&rft.spage=885&rft.epage=892&rft.pages=885-892&rft.issn=0125-1562&rft.coden=SJTMAK&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E69870057%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201467959&rft_id=info:pmid/19058585&rfr_iscdi=true |