Disseminated Bacillus Calmette–Guerin Infection after BCG Vaccination
The BCG is administered to all the newborns at birth in Iran. Systemic adverse reactions to BCG vaccine such as osteomyelitis and disseminated BCG infection are rare. This is a retrospective study of 15 cases
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Veröffentlicht in: | Journal of tropical pediatrics (1980) 2008-12, Vol.54 (6), p.413-416 |
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container_title | Journal of tropical pediatrics (1980) |
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creator | Rezai, Mohammad Sadegh Khotaei, Ghamartaj Mamishi, Setareh Kheirkhah, Maryam Parvaneh, Nima |
description | The BCG is administered to all the newborns at birth in Iran. Systemic adverse reactions to BCG vaccine such as osteomyelitis and disseminated BCG infection are rare. This is a retrospective study of 15 cases |
doi_str_mv | 10.1093/tropej/fmn053 |
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Systemic adverse reactions to BCG vaccine such as osteomyelitis and disseminated BCG infection are rare. This is a retrospective study of 15 cases <72 months who were admitted with systemic syndrome compatible with disseminated mycobacterial disease during 2004–07. Disseminated BCG disease occurred in eight children younger than 6-months old and 12 patient younger than 12-months old. Twelve patients were male. Nine of 15 patients had well known primary immune deficiency disorders including severe combined immunodeficiency, chronic granulomatous disease; cell mediated immune defect and HIV infection. Nine (60%) cases had good response to four anti-mycobacterial drug therapy and interferon gamma. Disseminated BCG disease is a rare but devastating complication of BCG vaccination that should be considered in the appropriate clinical setting. Severe immune-compromised infants are at greatest risk and they respond poorly to standard therapies.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmn053</identifier><identifier>PMID: 18593737</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; BCG ; BCG Vaccine - adverse effects ; BCG Vaccine - immunology ; Biological and medical sciences ; Cattle ; Child, Preschool ; Female ; General aspects ; Human bacterial diseases ; Humans ; immunodeficiency ; Immunologic Deficiency Syndromes - complications ; Immunologic Deficiency Syndromes - microbiology ; Infant ; Infant, Newborn ; Infectious diseases ; Iran - epidemiology ; Male ; Medical sciences ; Mycobacterium ; Mycobacterium bovis - immunology ; Mycobacterium bovis - isolation & purification ; Mycobacterium Infections - epidemiology ; Mycobacterium Infections - etiology ; Mycobacterium Infections - microbiology ; Retrospective Studies ; Risk Factors ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Bovine - complications ; vaccination ; Vaccination - adverse effects</subject><ispartof>Journal of tropical pediatrics (1980), 2008-12, Vol.54 (6), p.413-416</ispartof><rights>The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008</rights><rights>2009 INIST-CNRS</rights><rights>The Author [2008]. Published by Oxford University Press. All rights reserved. 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Systemic adverse reactions to BCG vaccine such as osteomyelitis and disseminated BCG infection are rare. This is a retrospective study of 15 cases <72 months who were admitted with systemic syndrome compatible with disseminated mycobacterial disease during 2004–07. Disseminated BCG disease occurred in eight children younger than 6-months old and 12 patient younger than 12-months old. Twelve patients were male. Nine of 15 patients had well known primary immune deficiency disorders including severe combined immunodeficiency, chronic granulomatous disease; cell mediated immune defect and HIV infection. Nine (60%) cases had good response to four anti-mycobacterial drug therapy and interferon gamma. Disseminated BCG disease is a rare but devastating complication of BCG vaccination that should be considered in the appropriate clinical setting. Severe immune-compromised infants are at greatest risk and they respond poorly to standard therapies.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>BCG</subject><subject>BCG Vaccine - adverse effects</subject><subject>BCG Vaccine - immunology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>immunodeficiency</subject><subject>Immunologic Deficiency Syndromes - complications</subject><subject>Immunologic Deficiency Syndromes - microbiology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium</subject><subject>Mycobacterium bovis - immunology</subject><subject>Mycobacterium bovis - isolation & purification</subject><subject>Mycobacterium Infections - epidemiology</subject><subject>Mycobacterium Infections - etiology</subject><subject>Mycobacterium Infections - microbiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Bovine - complications</subject><subject>vaccination</subject><subject>Vaccination - adverse effects</subject><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9rFDEUB_AgFrtWj15lEBQvY5O8JJM52q3OFgoi1SK9hEz2BWadH2syA3rzf_A_7F_SLDO04KUQCIRPvu8lj5BXjH5gtITTMQx73J36rqcSnpAVE0rmoJR4SlaUCZ4rAH1Mnse4o5RyLcQzcsy0LKGAYkWq8yZG7JrejrjNzqxr2naK2dq2HY4j3v79V00Ymj676D26sRn6zPoRQ3a2rrJr69zhZjp9QY68bSO-XPYT8v3zp2_rTX75pbpYf7zMnSgopMZ4oaSvhd5uwTolGAionSqddOBrjgU65QrvPKJkBbfKCm55zeqaacYlnJB3c-4-DL8mjKPpmuiwbW2PwxSNKnVarHwUcqqBFRoSfPMf3A1T6NMjDOcCBKPykJbPyIUhxoDe7EPT2fDHMGoOczDzHMw8h-RfL6FT3eH2QS8fn8DbBdjobOuD7V0T7x1nNKVqkdz72Q3T_tGaS49NHPH3Pbbhp1GppDSbHzfm_OrmK2yuK3MFdw1br7E</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Rezai, Mohammad Sadegh</creator><creator>Khotaei, Ghamartaj</creator><creator>Mamishi, Setareh</creator><creator>Kheirkhah, Maryam</creator><creator>Parvaneh, Nima</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7T2</scope><scope>7U2</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Disseminated Bacillus Calmette–Guerin Infection after BCG Vaccination</title><author>Rezai, Mohammad Sadegh ; Khotaei, Ghamartaj ; Mamishi, Setareh ; Kheirkhah, Maryam ; Parvaneh, Nima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4703-362765fb48dd3ac641343bc69c5c3fb2e7ec6c7fcfee5172a6a42a2b1bb181253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>BCG</topic><topic>BCG Vaccine - adverse effects</topic><topic>BCG Vaccine - immunology</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>immunodeficiency</topic><topic>Immunologic Deficiency Syndromes - complications</topic><topic>Immunologic Deficiency Syndromes - microbiology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycobacterium</topic><topic>Mycobacterium bovis - immunology</topic><topic>Mycobacterium bovis - isolation & purification</topic><topic>Mycobacterium Infections - epidemiology</topic><topic>Mycobacterium Infections - etiology</topic><topic>Mycobacterium Infections - microbiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Bovine - complications</topic><topic>vaccination</topic><topic>Vaccination - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezai, Mohammad Sadegh</creatorcontrib><creatorcontrib>Khotaei, Ghamartaj</creatorcontrib><creatorcontrib>Mamishi, Setareh</creatorcontrib><creatorcontrib>Kheirkhah, Maryam</creatorcontrib><creatorcontrib>Parvaneh, Nima</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezai, Mohammad Sadegh</au><au>Khotaei, Ghamartaj</au><au>Mamishi, Setareh</au><au>Kheirkhah, Maryam</au><au>Parvaneh, Nima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disseminated Bacillus Calmette–Guerin Infection after BCG Vaccination</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2008-12</date><risdate>2008</risdate><volume>54</volume><issue>6</issue><spage>413</spage><epage>416</epage><pages>413-416</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>The BCG is administered to all the newborns at birth in Iran. Systemic adverse reactions to BCG vaccine such as osteomyelitis and disseminated BCG infection are rare. This is a retrospective study of 15 cases <72 months who were admitted with systemic syndrome compatible with disseminated mycobacterial disease during 2004–07. Disseminated BCG disease occurred in eight children younger than 6-months old and 12 patient younger than 12-months old. Twelve patients were male. Nine of 15 patients had well known primary immune deficiency disorders including severe combined immunodeficiency, chronic granulomatous disease; cell mediated immune defect and HIV infection. Nine (60%) cases had good response to four anti-mycobacterial drug therapy and interferon gamma. Disseminated BCG disease is a rare but devastating complication of BCG vaccination that should be considered in the appropriate clinical setting. 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source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Bacterial diseases BCG BCG Vaccine - adverse effects BCG Vaccine - immunology Biological and medical sciences Cattle Child, Preschool Female General aspects Human bacterial diseases Humans immunodeficiency Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - microbiology Infant Infant, Newborn Infectious diseases Iran - epidemiology Male Medical sciences Mycobacterium Mycobacterium bovis - immunology Mycobacterium bovis - isolation & purification Mycobacterium Infections - epidemiology Mycobacterium Infections - etiology Mycobacterium Infections - microbiology Retrospective Studies Risk Factors Tuberculosis and atypical mycobacterial infections Tuberculosis, Bovine - complications vaccination Vaccination - adverse effects |
title | Disseminated Bacillus Calmette–Guerin Infection after BCG Vaccination |
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