Protein Kinase A Regulates 3-Phosphatidylinositide Dynamics during Platelet-derived Growth Factor-induced Membrane Ruffling and Chemotaxis

Spatial regulation of the cAMP-dependent protein kinase (PKA) is required for chemotaxis in fibroblasts; however, the mechanism(s) by which PKA regulates the cell migration machinery remain largely unknown. Here we report that one function of PKA during platelet-derived growth factor (PDGF)-induced...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2008-12, Vol.283 (50), p.35199-35211
Hauptverfasser:	Deming, Paula B., Campbell, Shirley L., Baldor, Linda C., Howe, Alan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Cell Membrane - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic AMP-Dependent Protein Kinases - physiology Fibroblasts - metabolism Gene Expression Regulation, Enzymologic Humans Inositol Phosphates - metabolism Mice Models, Biological Plasmids - metabolism Platelet-Derived Growth Factor - metabolism Rats Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!