Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”
Background: Prior studies suggest that auditory hallucinations of “voices” arise from activation of speech perception areas of the cerebral cortex. Low frequency transcranial magnetic stimulation (TMS) can reduce cortical activation. Methods: We have studied three schizophrenic patients reporting pe...
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| Veröffentlicht in: | Biological psychiatry (1969) 1999-07, Vol.46 (1), p.130-132 |
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| container_title | Biological psychiatry (1969) |
| container_volume | 46 |
| creator | Hoffman, Ralph E Boutros, Nashaat N Berman, Robert M Roessler, Elizabeth Belger, Aysenil Krystal, John H Charney, Dennis S |
| description | Background: Prior studies suggest that auditory hallucinations of “voices” arise from activation of speech perception areas of the cerebral cortex. Low frequency transcranial magnetic stimulation (TMS) can reduce cortical activation.
Methods: We have studied three schizophrenic patients reporting persistent auditory hallucinations to determine if low frequency TMS could curtail these experiences. One hertz stimulation of left temporoparietal cortex was compared with sham stimulation using a double-blind, cross-over design.
Results: All three patients demonstrated greater improvement in hallucination severity following active stimulation compared to sham stimulation. Two of the three patients reported near total cessation of hallucinations for ⩾ 2 weeks.
Conclusions: TMS may advance our understanding of the mechanism and treatment of auditory hallucinations. |
| doi_str_mv | 10.1016/S0006-3223(98)00358-8 |
| format | Article |
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Methods: We have studied three schizophrenic patients reporting persistent auditory hallucinations to determine if low frequency TMS could curtail these experiences. One hertz stimulation of left temporoparietal cortex was compared with sham stimulation using a double-blind, cross-over design.
Results: All three patients demonstrated greater improvement in hallucination severity following active stimulation compared to sham stimulation. Two of the three patients reported near total cessation of hallucinations for ⩾ 2 weeks.
Conclusions: TMS may advance our understanding of the mechanism and treatment of auditory hallucinations.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(98)00358-8</identifier><identifier>PMID: 10394483</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Auditory hallucinations ; Biological and medical sciences ; cerebral cortex ; Cross-Over Studies ; Double-Blind Method ; Female ; Hallucinations - psychology ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Parietal Lobe - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; psychosis ; Schizophrenia ; speech processing ; Temporal Lobe - physiology ; Transcranial Magnetic Stimulation ; Treatments</subject><ispartof>Biological psychiatry (1969), 1999-07, Vol.46 (1), p.130-132</ispartof><rights>1999 Society of Biological Psychiatry</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-b88cfe714456ebddc1a320ad42df428d7cffc650bb1c0644e365cedbc1687963</citedby><cites>FETCH-LOGICAL-c503t-b88cfe714456ebddc1a320ad42df428d7cffc650bb1c0644e365cedbc1687963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322398003588$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1878627$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10394483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoffman, Ralph E</creatorcontrib><creatorcontrib>Boutros, Nashaat N</creatorcontrib><creatorcontrib>Berman, Robert M</creatorcontrib><creatorcontrib>Roessler, Elizabeth</creatorcontrib><creatorcontrib>Belger, Aysenil</creatorcontrib><creatorcontrib>Krystal, John H</creatorcontrib><creatorcontrib>Charney, Dennis S</creatorcontrib><title>Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: Prior studies suggest that auditory hallucinations of “voices” arise from activation of speech perception areas of the cerebral cortex. Low frequency transcranial magnetic stimulation (TMS) can reduce cortical activation.
Methods: We have studied three schizophrenic patients reporting persistent auditory hallucinations to determine if low frequency TMS could curtail these experiences. One hertz stimulation of left temporoparietal cortex was compared with sham stimulation using a double-blind, cross-over design.
Results: All three patients demonstrated greater improvement in hallucination severity following active stimulation compared to sham stimulation. Two of the three patients reported near total cessation of hallucinations for ⩾ 2 weeks.
Conclusions: TMS may advance our understanding of the mechanism and treatment of auditory hallucinations.</description><subject>Adult</subject><subject>Auditory hallucinations</subject><subject>Biological and medical sciences</subject><subject>cerebral cortex</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Hallucinations - psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Parietal Lobe - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>psychosis</subject><subject>Schizophrenia</subject><subject>speech processing</subject><subject>Temporal Lobe - physiology</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Treatments</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Mtu1DAUgGELUdGh8AggLxCCRcC3OM6qQhWXSpW6YPaWc3LSGiVxsJ0R7Pog8HJ9EtzOCNh1Y8vS59tPyAvO3nHG9fuvjDFdSSHkm9a8ZUzWpjKPyIabRlZCMfGYbP6SY_I0pW9l2QjBn5BjzmSrlJEbsttGNycog3cjndzVjNkDTdlP6-iyDzMNAx1xyDTjtIQYFhc95oIhxIw_qJ9pvo6IdCkc55xoxOKyn6_otRvHFfzsMvb09ubXLnjAdHvz-xk5GtyY8PlhPiHbTx-3Z1-qi8vP52cfLiqomcxVZwwM2HClao1d3wN3UjDXK9EPSpi-gWEAXbOu48C0Uih1Ddh3wLVpWi1PyOv9sUsM31dM2U4-AY6jmzGsyerW6LYWdYH1HkIMKUUc7BL95OJPy5m9623ve9u7mLY19r63NWXfy8MFazdh_9-ufeACXh2AS-DGoYQGn_450xgtmsJO9wxLjJ3HaBOUmOUvPiJk2wf_wEv-AEr8of8</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Hoffman, Ralph E</creator><creator>Boutros, Nashaat N</creator><creator>Berman, Robert M</creator><creator>Roessler, Elizabeth</creator><creator>Belger, Aysenil</creator><creator>Krystal, John H</creator><creator>Charney, Dennis S</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”</title><author>Hoffman, Ralph E ; Boutros, Nashaat N ; Berman, Robert M ; Roessler, Elizabeth ; Belger, Aysenil ; Krystal, John H ; Charney, Dennis S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-b88cfe714456ebddc1a320ad42df428d7cffc650bb1c0644e365cedbc1687963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Auditory hallucinations</topic><topic>Biological and medical sciences</topic><topic>cerebral cortex</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Hallucinations - psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Parietal Lobe - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>psychosis</topic><topic>Schizophrenia</topic><topic>speech processing</topic><topic>Temporal Lobe - physiology</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoffman, Ralph E</creatorcontrib><creatorcontrib>Boutros, Nashaat N</creatorcontrib><creatorcontrib>Berman, Robert M</creatorcontrib><creatorcontrib>Roessler, Elizabeth</creatorcontrib><creatorcontrib>Belger, Aysenil</creatorcontrib><creatorcontrib>Krystal, John H</creatorcontrib><creatorcontrib>Charney, Dennis S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoffman, Ralph E</au><au>Boutros, Nashaat N</au><au>Berman, Robert M</au><au>Roessler, Elizabeth</au><au>Belger, Aysenil</au><au>Krystal, John H</au><au>Charney, Dennis S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>46</volume><issue>1</issue><spage>130</spage><epage>132</epage><pages>130-132</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: Prior studies suggest that auditory hallucinations of “voices” arise from activation of speech perception areas of the cerebral cortex. Low frequency transcranial magnetic stimulation (TMS) can reduce cortical activation.
Methods: We have studied three schizophrenic patients reporting persistent auditory hallucinations to determine if low frequency TMS could curtail these experiences. One hertz stimulation of left temporoparietal cortex was compared with sham stimulation using a double-blind, cross-over design.
Results: All three patients demonstrated greater improvement in hallucination severity following active stimulation compared to sham stimulation. Two of the three patients reported near total cessation of hallucinations for ⩾ 2 weeks.
Conclusions: TMS may advance our understanding of the mechanism and treatment of auditory hallucinations.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10394483</pmid><doi>10.1016/S0006-3223(98)00358-8</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Auditory hallucinations Biological and medical sciences cerebral cortex Cross-Over Studies Double-Blind Method Female Hallucinations - psychology Humans Male Medical sciences Middle Aged Miscellaneous Parietal Lobe - physiology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry psychosis Schizophrenia speech processing Temporal Lobe - physiology Transcranial Magnetic Stimulation Treatments |
| title | Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices” |
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