Severe Ocular Abnormalities in C57BL/6 but Not in 129/Sv p53-Deficient Mice

To demonstrate the importance of genetic background interaction on the development of ocular phenotypes in p53-deficient mice. Eyes of adult mice, homozygous and heterozygous for the p53 gene disruption in the 129/SvJ and C57BL/6J (B6) genetic backgrounds, and their F1 progeny were examined by indir...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1999-07, Vol.40 (8), p.1874-1878
Hauptverfasser:	Ikeda, Sakae, Hawes, Norman L, Chang, Bo, Avery, Cindy S, Smith, Richard S, Nishina, Patsy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - genetics Abnormalities, Multiple - pathology Animals Biological and medical sciences Cataract - genetics Cataract - pathology DNA Primers - chemistry Eye Abnormalities - genetics Eye Abnormalities - pathology Eye Diseases - genetics Eye Diseases - pathology Female Genes, p53 - genetics Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Ophthalmology Optic Nerve - abnormalities Optic Nerve - pathology Phenotype Retina - abnormalities Retina - pathology Retinal Dysplasia - genetics Retinal Dysplasia - pathology Retinopathies Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Vitreous Body - abnormalities Vitreous Body - pathology
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