The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats
1. 1. The effects of two unselective potassium (K +-) channel blockers, quinine (12.5, 25 and 50 mg/kg) and 4-aminopyridine (1 and 2 mg/kg), on conditioned place preference and biphasic changes in motor activity induced by morphine (10 mg/kg) were tested in Wistar rats. Quinine is known to block vol...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1999-05, Vol.23 (4), p.713-730 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Meririnne, Esa Kankaanpää, Aino Vanakoski, Jyrki Lillsunde, Pirjo Seppälä, Timo |
| description | 1.
1. The effects of two unselective potassium (K
+-) channel blockers, quinine (12.5, 25 and 50 mg/kg) and 4-aminopyridine (1 and 2 mg/kg), on conditioned place preference and biphasic changes in motor activity induced by morphine (10 mg/kg) were tested in Wistar rats. Quinine is known to block voltage-, calcium- and ATP-sensitive K
+-channels while 4-aminopyridine is known to block voltage- sensitive K
+-channels.
2.
2. In the counterbalanced method, quinine attenuated morphine-induced place preference, whereas 4-aminopyridine was ineffective. In the motor activity test measured with an Animex-activity meter neither of the K
+-channel blockers affected morphine-induced hypoactivity, but both K
+- channel blockers prevented morphine-induced secondary hyperactivity.
3.
3. These results suggest the involvement of quinine-sensitive but not 4-aminopyridine-sensitive K
+-channels in morphine reward. It is also suggested that the blockade of K
+-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine- induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K
+-channels. |
| doi_str_mv | 10.1016/S0278-5846(99)00030-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69867074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278584699000305</els_id><sourcerecordid>69867074</sourcerecordid><originalsourceid>FETCH-LOGICAL-c330t-6cad67e56fd3f224656b9ebe5ff78d92007535d48b8856c9554e4f9d68c20eb93</originalsourceid><addsrcrecordid>eNqFkU1vFSEUhonR2NvqT9CwMKYupjLDwMCqMY1fSZMurGvCwMGLmYEpzDS5-_5wmc6NuuuK5OV5D_CA0JuaXNSk5h9_kKYTFRMtP5fyAyGEkoo9Q7talLhtav4c7f4iJ-g0598FqimhL9FJTagkXSN36OF2DxicAzNnHB2-W3zwAbAOFreVHn2I0yF5u2YxYBOD9bOPASyeBm0ATwkcJAhm65i9Dr8gYx_wGOeYsDazv_fzoSR2MaXWH8pOmvbrxEIlPedX6IXTQ4bXx_UM_fzy-fbqW3V98_X71afrylBK5oobbXkHjDtLXdO0nPFeQg_MuU5Y2RDSMcpsK3ohGDeSsRZaJy0XpiHQS3qG3m9zpxTvFsizGn02MAw6QFyy4lLwjnRtAdkGmhRzLi9UU_KjTgdVE7XqV4_61epWSake9StWem-PByz9CPa_1ua7AO-OgM5GDy7pYHz-xwlCGykKdrlhUGzce0gqG786tj6Vn1I2-idu8gcwDqMy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69867074</pqid></control><display><type>article</type><title>The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Meririnne, Esa ; Kankaanpää, Aino ; Vanakoski, Jyrki ; Lillsunde, Pirjo ; Seppälä, Timo</creator><creatorcontrib>Meririnne, Esa ; Kankaanpää, Aino ; Vanakoski, Jyrki ; Lillsunde, Pirjo ; Seppälä, Timo</creatorcontrib><description>1.
1. The effects of two unselective potassium (K
+-) channel blockers, quinine (12.5, 25 and 50 mg/kg) and 4-aminopyridine (1 and 2 mg/kg), on conditioned place preference and biphasic changes in motor activity induced by morphine (10 mg/kg) were tested in Wistar rats. Quinine is known to block voltage-, calcium- and ATP-sensitive K
+-channels while 4-aminopyridine is known to block voltage- sensitive K
+-channels.
2.
2. In the counterbalanced method, quinine attenuated morphine-induced place preference, whereas 4-aminopyridine was ineffective. In the motor activity test measured with an Animex-activity meter neither of the K
+-channel blockers affected morphine-induced hypoactivity, but both K
+- channel blockers prevented morphine-induced secondary hyperactivity.
3.
3. These results suggest the involvement of quinine-sensitive but not 4-aminopyridine-sensitive K
+-channels in morphine reward. It is also suggested that the blockade of K
+-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine- induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K
+-channels.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/S0278-5846(99)00030-5</identifier><identifier>PMID: 10390729</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>4-aminopyridine ; 4-Aminopyridine - pharmacology ; Analgesics ; Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; conditioned place preference ; Conditioning, Operant - drug effects ; Fundamental and applied biological sciences. Psychology ; Male ; Medical sciences ; morphine ; Morphine - pharmacology ; motor activity ; Motor Activity - drug effects ; Neuropharmacology ; Neurotransmission and behavior ; Pharmacology. Drug treatments ; Potassium Channel Blockers ; potassium channels ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; quinine ; Quinine - pharmacology ; Rats ; Rats, Wistar ; reward</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 1999-05, Vol.23 (4), p.713-730</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-6cad67e56fd3f224656b9ebe5ff78d92007535d48b8856c9554e4f9d68c20eb93</citedby><cites>FETCH-LOGICAL-c330t-6cad67e56fd3f224656b9ebe5ff78d92007535d48b8856c9554e4f9d68c20eb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278584699000305$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1803298$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10390729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meririnne, Esa</creatorcontrib><creatorcontrib>Kankaanpää, Aino</creatorcontrib><creatorcontrib>Vanakoski, Jyrki</creatorcontrib><creatorcontrib>Lillsunde, Pirjo</creatorcontrib><creatorcontrib>Seppälä, Timo</creatorcontrib><title>The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>1.
1. The effects of two unselective potassium (K
+-) channel blockers, quinine (12.5, 25 and 50 mg/kg) and 4-aminopyridine (1 and 2 mg/kg), on conditioned place preference and biphasic changes in motor activity induced by morphine (10 mg/kg) were tested in Wistar rats. Quinine is known to block voltage-, calcium- and ATP-sensitive K
+-channels while 4-aminopyridine is known to block voltage- sensitive K
+-channels.
2.
2. In the counterbalanced method, quinine attenuated morphine-induced place preference, whereas 4-aminopyridine was ineffective. In the motor activity test measured with an Animex-activity meter neither of the K
+-channel blockers affected morphine-induced hypoactivity, but both K
+- channel blockers prevented morphine-induced secondary hyperactivity.
3.
3. These results suggest the involvement of quinine-sensitive but not 4-aminopyridine-sensitive K
+-channels in morphine reward. It is also suggested that the blockade of K
+-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine- induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K
+-channels.</description><subject>4-aminopyridine</subject><subject>4-Aminopyridine - pharmacology</subject><subject>Analgesics</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>conditioned place preference</subject><subject>Conditioning, Operant - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>morphine</subject><subject>Morphine - pharmacology</subject><subject>motor activity</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Neurotransmission and behavior</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium Channel Blockers</subject><subject>potassium channels</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>quinine</subject><subject>Quinine - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>reward</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEUhonR2NvqT9CwMKYupjLDwMCqMY1fSZMurGvCwMGLmYEpzDS5-_5wmc6NuuuK5OV5D_CA0JuaXNSk5h9_kKYTFRMtP5fyAyGEkoo9Q7talLhtav4c7f4iJ-g0598FqimhL9FJTagkXSN36OF2DxicAzNnHB2-W3zwAbAOFreVHn2I0yF5u2YxYBOD9bOPASyeBm0ATwkcJAhm65i9Dr8gYx_wGOeYsDazv_fzoSR2MaXWH8pOmvbrxEIlPedX6IXTQ4bXx_UM_fzy-fbqW3V98_X71afrylBK5oobbXkHjDtLXdO0nPFeQg_MuU5Y2RDSMcpsK3ohGDeSsRZaJy0XpiHQS3qG3m9zpxTvFsizGn02MAw6QFyy4lLwjnRtAdkGmhRzLi9UU_KjTgdVE7XqV4_61epWSake9StWem-PByz9CPa_1ua7AO-OgM5GDy7pYHz-xwlCGykKdrlhUGzce0gqG786tj6Vn1I2-idu8gcwDqMy</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>Meririnne, Esa</creator><creator>Kankaanpää, Aino</creator><creator>Vanakoski, Jyrki</creator><creator>Lillsunde, Pirjo</creator><creator>Seppälä, Timo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199905</creationdate><title>The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats</title><author>Meririnne, Esa ; Kankaanpää, Aino ; Vanakoski, Jyrki ; Lillsunde, Pirjo ; Seppälä, Timo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-6cad67e56fd3f224656b9ebe5ff78d92007535d48b8856c9554e4f9d68c20eb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>4-aminopyridine</topic><topic>4-Aminopyridine - pharmacology</topic><topic>Analgesics</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>conditioned place preference</topic><topic>Conditioning, Operant - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>morphine</topic><topic>Morphine - pharmacology</topic><topic>motor activity</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>Neurotransmission and behavior</topic><topic>Pharmacology. Drug treatments</topic><topic>Potassium Channel Blockers</topic><topic>potassium channels</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>quinine</topic><topic>Quinine - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>reward</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meririnne, Esa</creatorcontrib><creatorcontrib>Kankaanpää, Aino</creatorcontrib><creatorcontrib>Vanakoski, Jyrki</creatorcontrib><creatorcontrib>Lillsunde, Pirjo</creatorcontrib><creatorcontrib>Seppälä, Timo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meririnne, Esa</au><au>Kankaanpää, Aino</au><au>Vanakoski, Jyrki</au><au>Lillsunde, Pirjo</au><au>Seppälä, Timo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>1999-05</date><risdate>1999</risdate><volume>23</volume><issue>4</issue><spage>713</spage><epage>730</epage><pages>713-730</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>1.
1. The effects of two unselective potassium (K
+-) channel blockers, quinine (12.5, 25 and 50 mg/kg) and 4-aminopyridine (1 and 2 mg/kg), on conditioned place preference and biphasic changes in motor activity induced by morphine (10 mg/kg) were tested in Wistar rats. Quinine is known to block voltage-, calcium- and ATP-sensitive K
+-channels while 4-aminopyridine is known to block voltage- sensitive K
+-channels.
2.
2. In the counterbalanced method, quinine attenuated morphine-induced place preference, whereas 4-aminopyridine was ineffective. In the motor activity test measured with an Animex-activity meter neither of the K
+-channel blockers affected morphine-induced hypoactivity, but both K
+- channel blockers prevented morphine-induced secondary hyperactivity.
3.
3. These results suggest the involvement of quinine-sensitive but not 4-aminopyridine-sensitive K
+-channels in morphine reward. It is also suggested that the blockade of K
+-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine- induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K
+-channels.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>10390729</pmid><doi>10.1016/S0278-5846(99)00030-5</doi><tpages>18</tpages></addata></record> |
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| subjects | 4-aminopyridine 4-Aminopyridine - pharmacology Analgesics Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences conditioned place preference Conditioning, Operant - drug effects Fundamental and applied biological sciences. Psychology Male Medical sciences morphine Morphine - pharmacology motor activity Motor Activity - drug effects Neuropharmacology Neurotransmission and behavior Pharmacology. Drug treatments Potassium Channel Blockers potassium channels Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology quinine Quinine - pharmacology Rats Rats, Wistar reward |
| title | The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats |
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