Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes

Invasion is an essential cellular response that plays an important role in a number of physiological and pathological processes. Matrix metalloproteinase (MMP) production and cell movement are diverse cellular responses integral to the process of invasion. The complexity of the invasive process sugg...

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Veröffentlicht in:	Journal of cellular physiology 1999-08, Vol.180 (2), p.271-284
Hauptverfasser:	Zeigler, Mary E., Chi, Yiqing, Schmidt, Tanja, Varani, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Antibody Complex Calcium-Calmodulin-Dependent Protein Kinases - analysis Calcium-Calmodulin-Dependent Protein Kinases - immunology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Division - drug effects Cell Division - physiology Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Collagenases - metabolism Epidermal Growth Factor - pharmacology Epidermis - cytology Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Fibroblast Growth Factors Gene Expression Regulation, Enzymologic Growth Substances - pharmacology Hepatocyte Growth Factor - pharmacology Humans Immunoblotting Insulin-Like Growth Factor I - pharmacology JNK Mitogen-Activated Protein Kinases Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - enzymology Kinetics Luciferases MAP Kinase Kinase 1 MAP Kinase Kinase 2 MAP Kinase Kinase 4 Matrix Metalloproteinase 9 Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Protein Kinases - analysis Protein Kinases - immunology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - immunology Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - analysis Protein-Tyrosine Kinases - immunology Protein-Tyrosine Kinases - metabolism Signal Transduction - physiology Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism
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