Ab initio fold prediction of small helical proteins using distance geometry and knowledge-based scoring functions

The problem of protein tertiary structure prediction from primary sequence can be separated into two subproblems: generation of a library of possible folds and specification of a best fold given the library. A distance geometry procedure based on random pairwise metrization with good sampling proper...

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Veröffentlicht in:	Journal of molecular biology 1999-07, Vol.290 (1), p.267-281
Hauptverfasser:	Huang, E S, Samudrala, R, Ponder, J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Proteins - chemistry
Online-Zugang:	Volltext
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