Protective effects of C5a blockade in sepsis

Sepsis in humans is a difficult condition to treat and is often associated with a high mortality rate. In this study, we induced sepsis in rats using cecal ligation and puncture (CLP). In rats depleted of the complement factor C3, CLP led to very short survival times (about 4 days). Of the rats that...

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Veröffentlicht in:	Nature medicine 1999-07, Vol.5 (7), p.788-792
Hauptverfasser:	Czermak, Boris J., Sarma, Vidya, Pierson, Carl L., Warner, Roscoe L., Huber-Lang, Markus, Bless, Nicolas M., Schmal, Hagen, Friedl, Hans Peter, Ward, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacteremia - blood Bacteremia - therapy Biomedical and Life Sciences Biomedicine Cancer Research Complement C5a - antagonists & inhibitors Complement C5a - chemistry Complement C5a - immunology Immunoglobulin G - therapeutic use Infectious Diseases Male Metabolic Diseases Molecular Medicine Molecular Sequence Data Neurosciences Neutrophils - physiology Peptide Fragments - chemistry Peptide Fragments - immunology Rabbits Rats Rats, Long-Evans Survival Rate
Online-Zugang:	Volltext
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