CagA of Helicobacter pylori alters the expression and cellular distribution of host proteins involved in cell signaling

To expand our knowledge of Helicobacter pylori virulence mechanisms, we used iTRAQ (isobaric tagging reagents for relative and absolute quantification)-based proteomic analysis to investigate the effect of H. pylori on gastric AGS tissue culture cells. In particular, we were interested in finding ou...

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Veröffentlicht in:	FEMS microbiology letters 2008-11, Vol.288 (2), p.227-234
Hauptverfasser:	Zeaiter, Zaher, Huynh, Hien Q, Kanyo, Richard, Stein, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial diseases Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Cell adhesion & migration Cell culture Cell Line, Tumor Cell migration Cytoskeletal Proteins - metabolism Cytotoxicity Cytotoxins Domains Ezrin Fundamental and applied biological sciences. Psychology Gastric Mucosa - cytology Gastric Mucosa - microbiology Gene Expression Regulation Genetics Helicobacter Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - pathogenicity Humans iTRAQ Lipids Membrane Microdomains - microbiology Microbiology Polarity Proteins Proteins - genetics Proteins - metabolism Proteomics rab GTP-Binding Proteins - metabolism Reagents Signal Transduction Syndecan Syndecan-4 - metabolism Tissue culture Toxicity Toxins Virulence
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