Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain
The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function. To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as fo...
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| creator | Patel, Pooja Nandwani Vyas, Rakesh K Bhavsar, Devang C Suryanarayan, U K Pelagade, Satish Patel, Dipak |
| description | The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function.
To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as follows: success was defined as angiographic obliteration and failure as residual lesion, requiring retreatment, or death due to hemorrhage from the AVM.
From May 2002 to May 2007, 54 patients were enrolled for this study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%, grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated by microsurgical resection out of which Grade I was seen in 5 patients, Grade II was seen in 17 patients, Grade III was seen in 9 patients and Grade V was seen in 7 patients. Rest of the sixteen patients were treated by linear accelerator radiosurgery out of which Grade II was seen in 6 patients, Grade III was seen in 5 patients and Grade IV was seen in 5 patients. The follow up was in range of 3-63 months. In follow up, digital subtraction angiography/ magnetic resonance angiography (DSA/MRA) was performed 3 months after surgery and 1 year and 2 years after stereotactic radiosurgery (SRS).
Among the patients treated with X-knife, 12/16 (75%) had proven angiographic obliteration. Complications were seen in 4/16 (25%) patients. Among the patients treated with microsurgical resection, 23/38 (61%) had proven angiographic obliteration. Complications (both intraoperative and postoperative) were seen in 19/38 (50%) patients.
Sixty-one percent of patients were candidates for surgical resection. X-knife is a good modality of treatment for a low-grade AVM situated in eloquent areas of the brain and also for high-grade AVMs, when the surgical risk and morbidity is high. |
| doi_str_mv | 10.4103/0973-1482.44287 |
| format | Article |
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To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as follows: success was defined as angiographic obliteration and failure as residual lesion, requiring retreatment, or death due to hemorrhage from the AVM.
From May 2002 to May 2007, 54 patients were enrolled for this study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%, grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated by microsurgical resection out of which Grade I was seen in 5 patients, Grade II was seen in 17 patients, Grade III was seen in 9 patients and Grade V was seen in 7 patients. Rest of the sixteen patients were treated by linear accelerator radiosurgery out of which Grade II was seen in 6 patients, Grade III was seen in 5 patients and Grade IV was seen in 5 patients. The follow up was in range of 3-63 months. In follow up, digital subtraction angiography/ magnetic resonance angiography (DSA/MRA) was performed 3 months after surgery and 1 year and 2 years after stereotactic radiosurgery (SRS).
Among the patients treated with X-knife, 12/16 (75%) had proven angiographic obliteration. Complications were seen in 4/16 (25%) patients. Among the patients treated with microsurgical resection, 23/38 (61%) had proven angiographic obliteration. Complications (both intraoperative and postoperative) were seen in 19/38 (50%) patients.
Sixty-one percent of patients were candidates for surgical resection. X-knife is a good modality of treatment for a low-grade AVM situated in eloquent areas of the brain and also for high-grade AVMs, when the surgical risk and morbidity is high.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.44287</identifier><identifier>PMID: 19052389</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Angiography - methods ; Arteriovenous malformations ; Brain - surgery ; Care and treatment ; Cerebral Angiography - methods ; Charged particles ; Excision (Surgery) ; Female ; Health aspects ; Humans ; Intracranial Arteriovenous Malformations - surgery ; Male ; Medical imaging ; Middle Aged ; Morbidity ; Mortality ; Radiosurgery - instrumentation ; Radiosurgery - methods ; Risk factors ; Surgery ; Treatment Outcome ; Veins & arteries</subject><ispartof>Journal of cancer research and therapeutics, 2008-10, Vol.4 (4), p.169-172</ispartof><rights>COPYRIGHT 2008 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Oct 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-80b00d7315b050abed41a6b362cc31868c8cd2d8042cdab294f371b2fdeb83063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19052389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Pooja Nandwani</creatorcontrib><creatorcontrib>Vyas, Rakesh K</creatorcontrib><creatorcontrib>Bhavsar, Devang C</creatorcontrib><creatorcontrib>Suryanarayan, U K</creatorcontrib><creatorcontrib>Pelagade, Satish</creatorcontrib><creatorcontrib>Patel, Dipak</creatorcontrib><title>Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function.
To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as follows: success was defined as angiographic obliteration and failure as residual lesion, requiring retreatment, or death due to hemorrhage from the AVM.
From May 2002 to May 2007, 54 patients were enrolled for this study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%, grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated by microsurgical resection out of which Grade I was seen in 5 patients, Grade II was seen in 17 patients, Grade III was seen in 9 patients and Grade V was seen in 7 patients. Rest of the sixteen patients were treated by linear accelerator radiosurgery out of which Grade II was seen in 6 patients, Grade III was seen in 5 patients and Grade IV was seen in 5 patients. The follow up was in range of 3-63 months. In follow up, digital subtraction angiography/ magnetic resonance angiography (DSA/MRA) was performed 3 months after surgery and 1 year and 2 years after stereotactic radiosurgery (SRS).
Among the patients treated with X-knife, 12/16 (75%) had proven angiographic obliteration. Complications were seen in 4/16 (25%) patients. Among the patients treated with microsurgical resection, 23/38 (61%) had proven angiographic obliteration. Complications (both intraoperative and postoperative) were seen in 19/38 (50%) patients.
Sixty-one percent of patients were candidates for surgical resection. X-knife is a good modality of treatment for a low-grade AVM situated in eloquent areas of the brain and also for high-grade AVMs, when the surgical risk and morbidity is high.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Angiography - methods</subject><subject>Arteriovenous malformations</subject><subject>Brain - surgery</subject><subject>Care and treatment</subject><subject>Cerebral Angiography - methods</subject><subject>Charged particles</subject><subject>Excision (Surgery)</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intracranial Arteriovenous Malformations - surgery</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Radiosurgery - instrumentation</subject><subject>Radiosurgery - methods</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Veins & arteries</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU2LFDEQhoMo7rh69iaNwt56Nl-dTh-HRVdhwYMK3kI-KkPW7mRNuoX596Z3BkUZ6hCoet6qVL0IvSZ4ywlm13joWUu4pFvOqeyfoA0ZBtlywuRTtPlTvUAvSrnHuOsplc_RBRlwR5kcNujLLurxUEJpkm--tz9i8NDo6Jqy5D3kQxNiM2fQ8wRxXhmdZ8gh_YKYltJMevQpT3oOKa5Vk3WIL9Ezr8cCr07vJfr24f3Xm4_t3efbTze7u9ZyIedWYoOx6xnpDO6wNuA40cIwQa1lRApppXXUScypddrQgXvWE0O9AyMZFuwSXR37PuT0c4EyqykUC-OoI9TPKTFIweoJKvj2P_A-LbkuXpQUVIqB9F2F3h2hvR5BhejTnLVdO6odkfWqQjzObM9Qe4iQ9Zgi-FDT__DbM3wNB1OwZwXXR4HNqZQMXj3kMOl8UASr1XO1uqpWV9Wj51Xx5rTdYiZwf_mTyew36cakeQ</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Patel, Pooja Nandwani</creator><creator>Vyas, Rakesh K</creator><creator>Bhavsar, Devang C</creator><creator>Suryanarayan, U K</creator><creator>Pelagade, Satish</creator><creator>Patel, Dipak</creator><general>Medknow Publications and Media Pvt. 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Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Pooja Nandwani</au><au>Vyas, Rakesh K</au><au>Bhavsar, Devang C</au><au>Suryanarayan, U K</au><au>Pelagade, Satish</au><au>Patel, Dipak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>4</volume><issue>4</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function.
To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as follows: success was defined as angiographic obliteration and failure as residual lesion, requiring retreatment, or death due to hemorrhage from the AVM.
From May 2002 to May 2007, 54 patients were enrolled for this study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%, grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated by microsurgical resection out of which Grade I was seen in 5 patients, Grade II was seen in 17 patients, Grade III was seen in 9 patients and Grade V was seen in 7 patients. Rest of the sixteen patients were treated by linear accelerator radiosurgery out of which Grade II was seen in 6 patients, Grade III was seen in 5 patients and Grade IV was seen in 5 patients. The follow up was in range of 3-63 months. In follow up, digital subtraction angiography/ magnetic resonance angiography (DSA/MRA) was performed 3 months after surgery and 1 year and 2 years after stereotactic radiosurgery (SRS).
Among the patients treated with X-knife, 12/16 (75%) had proven angiographic obliteration. Complications were seen in 4/16 (25%) patients. Among the patients treated with microsurgical resection, 23/38 (61%) had proven angiographic obliteration. Complications (both intraoperative and postoperative) were seen in 19/38 (50%) patients.
Sixty-one percent of patients were candidates for surgical resection. X-knife is a good modality of treatment for a low-grade AVM situated in eloquent areas of the brain and also for high-grade AVMs, when the surgical risk and morbidity is high.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>19052389</pmid><doi>10.4103/0973-1482.44287</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Medknow Open Access Medical Journals; Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Angiography - methods Arteriovenous malformations Brain - surgery Care and treatment Cerebral Angiography - methods Charged particles Excision (Surgery) Female Health aspects Humans Intracranial Arteriovenous Malformations - surgery Male Medical imaging Middle Aged Morbidity Mortality Radiosurgery - instrumentation Radiosurgery - methods Risk factors Surgery Treatment Outcome Veins & arteries |
| title | Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain |
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