In vitro modulation of human keratinocyte pro- and anti-inflammatory cytokine production by the capsule of Malassezia species

Abstract Malassezia spp. are commensal, cutaneous fungi that are implicated in seborrhoeic dermatitis. We hypothesize that the lipid-rich capsule of Malassezia spp. masks the organism from host detection, and depletion of this layer elicits an inflammatory response. To test this, preparations of cap...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2008-11, Vol.54 (2), p.203-214
Hauptverfasser:	Thomas, Daniel S., Ingham, Eileen, Bojar, Richard A., Holland, Keith T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Biological and medical sciences capsule Cell Survival Cell Wall - physiology Cells, Cultured Cytokines Depletion Dermatitis Dermatomycoses - microbiology Fundamental and applied biological sciences. Psychology Fungi Humans Immunoassays immunoevasion Inflammation Inflammatory response Interleukin 10 Interleukin 6 Interleukin 8 Interleukins - biosynthesis Intracellular Keratinocytes Keratinocytes - cytology Keratinocytes - metabolism Lipids Lipids - physiology Malassezia Malassezia - physiology Malassezia furfur Malassezia sympodialis Masks Microbiology Microscopy, Electron, Transmission Miscellaneous Mycology Pathogenesis seborrheic dermatitis Skin - microbiology Stationary phase Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-α Tumors Yeast Yeasts
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