Rapid Disappearance of Zaleplon from Breast Milk after Oral Administration to Lactating Women

Five lactating mothers were administered the therapeutic dose of zaleplon (10 mg) orally in an open‐label, single‐dose, pharmacokinetic study. Plasma and breast milk were sampled through 8 hours after dose administration for subsequent determinations of zaleplon and its major, though inactive, plasm...

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Veröffentlicht in:	Journal of clinical pharmacology 1999-07, Vol.39 (7), p.670-674
Hauptverfasser:	Darwish, Mona, Martin, Patrick T., Cevallos, William H., Tse, Susanna, Wheeler, Sarah, Troy, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - blood Acetamides - pharmacokinetics Administration, Oral Adolescent Adult Area Under Curve Biological and medical sciences Biological Availability Breast Feeding Female Humans Hypnotics and Sedatives - pharmacokinetics Hypnotics. Sedatives Lactation - metabolism Medical sciences Metabolic Clearance Rate Milk, Human - metabolism Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrimidines - blood Pyrimidines - pharmacokinetics
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