The Murine Antiapoptotic Protein A1 Is Induced in Inflammatory Macrophages and Constitutively Expressed in Neutrophils

Myeloid leukocytes are thought to regulate their susceptibility to apoptosis upon migration to a site of inflammation. However, factors that determine survival have not been well characterized in these cells. We have examined the expression of murine A1, an antiapoptotic Bcl-2 relative found in acti...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-07, Vol.163 (1), p.412-419
Hauptverfasser:	Orlofsky, Amos, Somogyi, Robert D, Weiss, Louis M, Prystowsky, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology bcl-2-Associated X Protein DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - blood DNA-Binding Proteins - genetics Female Homeodomain Proteins Inflammation - immunology Inflammation - parasitology Inflammation - pathology Macrophages - metabolism Macrophages - pathology Mice Mice, Inbred BALB C Minor Histocompatibility Antigens Neutrophils - metabolism Neutrophils - pathology Peritoneal Cavity - parasitology Peritoneal Cavity - pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Replication Protein C Repressor Proteins RNA, Messenger - biosynthesis RNA, Messenger - metabolism Saccharomyces cerevisiae Proteins Subcellular Fractions - immunology Subcellular Fractions - metabolism Toxoplasma - immunology Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - metabolism Toxoplasmosis, Animal - pathology
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