Farnesol and Geranylgeraniol Prevent Activation of Caspases by Aminobisphosphonates: Biochemical Evidence for Two Distinct Pharmacological Classes of Bisphosphonate Drugs

Recently, advances have been made in understanding the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Studies with the macrophage-like cell line J774 have suggested that alendronate, an amino-containing bisphosphonate, causes apoptosis by preventing post-translational mo...

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Veröffentlicht in:	Molecular pharmacology 1999-07, Vol.56 (1), p.131-140
Hauptverfasser:	Benford, H L, Frith, J C, Auriola, S, Mönkkönen, J, Rogers, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Alendronate - pharmacology Animals Apoptosis Caspase 3 Caspase Inhibitors Cells, Cultured Diphosphonates - pharmacology Diterpenes - pharmacology Endopeptidases - metabolism Enzyme Activation - drug effects Farnesol - pharmacology Mice Protein Prenylation - drug effects
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