Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging

Flow and oxygenation dependent (FLOOD) MR images of GH3 prolactinomas display large intensity increases in response to carbogen (5% CO2/95% O2) breathing. To assess the relative contributions of carbon dioxide and oxygen to this response and the tumour oxygenation state, the response of GH3 prolacti...

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Veröffentlicht in:	NMR in biomedicine 1999-04, Vol.12 (2), p.98-106
Hauptverfasser:	Robinson, Simon P., Collingridge, David R., Howe, Franklyn A., Rodrigues, Loreta M., Chaplin, David J., Griffiths, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences blood flow carbogen Carbon Dioxide - administration & dosage Carbon Dioxide - blood Cell Hypoxia Endocrinopathies Female Hydrogen-Ion Concentration Hypercapnia - blood Hypercapnia - metabolism Hypothalamus. Hypophysis. Epiphysis (diseases) Magnetic Resonance Imaging - methods Medical sciences Monitoring, Physiologic - methods MRI Non tumoral diseases. Target tissue resistance. Benign neoplasms Oxygen - administration & dosage Oxygen - blood Oxygen - metabolism oxygenation Partial Pressure Pituitary Neoplasms - blood supply Pituitary Neoplasms - metabolism Pituitary Neoplasms - radiotherapy Prolactinoma - blood supply Prolactinoma - metabolism Prolactinoma - radiotherapy Radiation-Sensitizing Agents - administration & dosage radiotherapy Rats Rats, Inbred WF
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