Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-α

Adoptive immunotherapy in form of donor leukocyte infusions is effective in a significant number of patients with chronic myeloid leukemia (CML) that have relapsed after allogeneic bone marrow transplantation (BMT). However, the therapy is associated with clinically significant side effects such as...

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Veröffentlicht in:	Experimental hematology 1999-07, Vol.27 (7), p.1176-1184
Hauptverfasser:	Wang, Chun, Al-Omar, Hamad M, Radvanyi, Laszlo, Banerjee, Avik, Bouman, Derek, Squire, Jeremy, Messner, Hans A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - genetics B7-1 Antigen - biosynthesis B7-1 Antigen - genetics B7-2 Antigen Bone Marrow - drug effects Bone Marrow - pathology Bone Marrow Cells - drug effects Cell Differentiation Chronic myeloid leukemia—Dendritic cell—Interferon-α Clone Cells - drug effects Clone Cells - immunology Clone Cells - pathology Cytotoxicity, Immunologic - drug effects Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - pathology Fusion Proteins, bcr-abl - analysis Gene Expression Regulation - drug effects Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology HLA Antigens - biosynthesis HLA Antigens - genetics Humans Immunophenotyping Immunotherapy, Adoptive In Situ Hybridization, Fluorescence Interferon-alpha - pharmacology Interleukin-4 - pharmacology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Lymphocyte Culture Test, Mixed Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Neoplasm Proteins - analysis T-Lymphocyte Subsets - immunology Tumor Necrosis Factor-alpha - pharmacology
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