Profilaggrin requires both linker and filaggrin peptide sequences to form granules : Implications for profilaggrin processing in vivo

Filaggrin is an intermediate filament associated protein that aids the packing of keratin filaments during terminal differentiation of keratinocytes. Premature aggregation of keratin filaments is prevented by filaggrin expression as the inactive precursor, profilaggrin, which is localized in keratoh...

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Veröffentlicht in:	Journal of investigative dermatology 1999-06, Vol.112 (6), p.843-852
Hauptverfasser:	KUECHLE, M. K, THULIN, C. D, PRESLAND, R. B, DALE, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cytoplasmic Granules - ultrastructure Dermatology Humans Intermediate Filament Proteins - chemistry Intermediate Filament Proteins - metabolism Intermediate Filament Proteins - physiology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptides - metabolism Protein Binding Protein Precursors - metabolism Protein Precursors - physiology Protein Processing, Post-Translational Skin Diseases - metabolism Solubility
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