A Non-AUG-Defined Alternative Open Reading Frame of the Intestinal Carboxyl Esterase mRNA Generates an Epitope Recognized by Renal Cell Carcinoma-Reactive Tumor-Infiltrating Lymphocytes In Situ

A number of Ags recognized by tumor-reactive T cells have been characterized, including nonmutated gene products and a variety of epitopes shown to arise from either mutated or alternatively processed transcripts. Here, we report that the screening of a cDNA library with an HLA-B7-restricted renal c...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-07, Vol.163 (1), p.483-490
Hauptverfasser:	Ronsin, Christophe, Chung-Scott, Veronique, Poullion, Isabelle, Aknouche, Nicolas, Gaudin, Catherine, Triebel, Frederic
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - immunology Amino Acid Sequence Antigen Presentation - genetics Antigens, Neoplasm - genetics Base Sequence Carboxylesterase Carboxylic Ester Hydrolases - genetics Carboxylic Ester Hydrolases - immunology Carboxylic Ester Hydrolases - metabolism Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Cell Differentiation - genetics Cell Separation Clone Cells Codon, Initiator - immunology DNA, Complementary - isolation & purification Epitopes, T-Lymphocyte - metabolism Humans Intestines - enzymology Kidney Neoplasms Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocyte Subsets - pathology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Male Middle Aged Molecular Sequence Data Open Reading Frames - immunology Organ Specificity - genetics Organ Specificity - immunology Peptides - genetics Peptides - immunology Peptides - metabolism Receptors, Antigen, T-Cell, alpha-beta - genetics RNA, Messenger - immunology RNA, Messenger - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - pathology Tumor Cells, Cultured
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