Thiol Depletion Induces Apoptosis in Cultured Lung Fibroblasts

Thiol antioxidants are implicated in the protection of cells from oxidative injury. We studied the role of thiols in the regulation of apoptosis in cultured lung fibroblasts. Thiol depletion by culturing fibroblasts in cystine-free medium or with thiol-depleting agents induced oxidant accumulation a...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1999-07, Vol.21 (1), p.54-64
Hauptverfasser:	Aoshiba, Kazutetsu, Yasui, Shuji, Nishimura, Kazuyuki, Nagai, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Cells, Cultured Cysteine - pharmacology Fibroblasts Glutathione - analysis Humans Leukotrienes - biosynthesis Lipoxygenase Inhibitors Lung - cytology Lung - drug effects Reactive Oxygen Species Sulfhydryl Compounds - analysis Sulfhydryl Compounds - physiology Time Factors Wound Healing
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