Urine free beta-hCG and total estriol for Down syndrome screening during the second trimester in an Asian population
Objective: To evaluate second-trimester free β-hCG and total estriol (E3) in the maternal urine as markers for Down syndrome screening in an Asian population. Methods: Free β-hCG and total E3 were measured in the urine samples of 28 Taiwanese Down syndrome pregnancies and 268 unaffected singleton pr...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1999-07, Vol.94 (1), p.107-111 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Hsu, Jenn J Hsu, Te Y Hsieh, T’Sang T Soong, Yung K Hsieh, Fon J Spencer, Kevin |
| description | Objective: To evaluate second-trimester free β-hCG and total estriol (E3) in the maternal urine as markers for Down syndrome screening in an Asian population.
Methods: Free β-hCG and total E3 were measured in the urine samples of 28 Taiwanese Down syndrome pregnancies and 268 unaffected singleton pregnancies at 14–25 weeks. Results were normalized to urine creatinine concentrations and converted to multiples of the median (MoM) levels. Gestational ages were estimated by ultrasound measurements.
Results: Median values of free β-hCG, total E3, free β-hCG to total E3 ratio, and the free β-hCG to total E3 MoM ratio in Down syndrome pregnancies were 4.75 MoM, 0.66 MoM, 8.99 MoM, and 9.51, respectively. At a 5% false-positive rate, the observed detection rates were 36% (ten of 28) with total E3, 71% (20 of 28) with free β-hCG, 68% (19 of 28) with free β-hCG/total E3, and 71% (20 of 28) with free β-hCG/total E3 MoM. When combined with maternal age, the expected detection rates were 65% with total E3, 71% with free β-hCG, 76% with free β-hCG/total E3, 80% with free β-hCG/total E3 MoM, and 89% when combining free β-hCG, total E3, and maternal age.
Conclusion: Urine free β-hCG and total E3 are useful markers for Down syndrome screening during the second trimester in Taiwanese women. |
| doi_str_mv | 10.1016/S0029-7844(99)00010-1 |
| format | Article |
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Methods: Free β-hCG and total E3 were measured in the urine samples of 28 Taiwanese Down syndrome pregnancies and 268 unaffected singleton pregnancies at 14–25 weeks. Results were normalized to urine creatinine concentrations and converted to multiples of the median (MoM) levels. Gestational ages were estimated by ultrasound measurements.
Results: Median values of free β-hCG, total E3, free β-hCG to total E3 ratio, and the free β-hCG to total E3 MoM ratio in Down syndrome pregnancies were 4.75 MoM, 0.66 MoM, 8.99 MoM, and 9.51, respectively. At a 5% false-positive rate, the observed detection rates were 36% (ten of 28) with total E3, 71% (20 of 28) with free β-hCG, 68% (19 of 28) with free β-hCG/total E3, and 71% (20 of 28) with free β-hCG/total E3 MoM. When combined with maternal age, the expected detection rates were 65% with total E3, 71% with free β-hCG, 76% with free β-hCG/total E3, 80% with free β-hCG/total E3 MoM, and 89% when combining free β-hCG, total E3, and maternal age.
Conclusion: Urine free β-hCG and total E3 are useful markers for Down syndrome screening during the second trimester in Taiwanese women.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1016/S0029-7844(99)00010-1</identifier><identifier>PMID: 10389728</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Chorionic Gonadotropin, beta Subunit, Human - urine ; Down Syndrome - diagnosis ; Estriol - urine ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy. Fetus. Placenta ; Prenatal Diagnosis - methods ; Taiwan ; Tropical medicine</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1999-07, Vol.94 (1), p.107-111</ispartof><rights>1999 The American College of Obstetricians and Gynecologists</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1868488$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10389728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Jenn J</creatorcontrib><creatorcontrib>Hsu, Te Y</creatorcontrib><creatorcontrib>Hsieh, T’Sang T</creatorcontrib><creatorcontrib>Soong, Yung K</creatorcontrib><creatorcontrib>Hsieh, Fon J</creatorcontrib><creatorcontrib>Spencer, Kevin</creatorcontrib><title>Urine free beta-hCG and total estriol for Down syndrome screening during the second trimester in an Asian population</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Objective: To evaluate second-trimester free β-hCG and total estriol (E3) in the maternal urine as markers for Down syndrome screening in an Asian population.
Methods: Free β-hCG and total E3 were measured in the urine samples of 28 Taiwanese Down syndrome pregnancies and 268 unaffected singleton pregnancies at 14–25 weeks. Results were normalized to urine creatinine concentrations and converted to multiples of the median (MoM) levels. Gestational ages were estimated by ultrasound measurements.
Results: Median values of free β-hCG, total E3, free β-hCG to total E3 ratio, and the free β-hCG to total E3 MoM ratio in Down syndrome pregnancies were 4.75 MoM, 0.66 MoM, 8.99 MoM, and 9.51, respectively. At a 5% false-positive rate, the observed detection rates were 36% (ten of 28) with total E3, 71% (20 of 28) with free β-hCG, 68% (19 of 28) with free β-hCG/total E3, and 71% (20 of 28) with free β-hCG/total E3 MoM. When combined with maternal age, the expected detection rates were 65% with total E3, 71% with free β-hCG, 76% with free β-hCG/total E3, 80% with free β-hCG/total E3 MoM, and 89% when combining free β-hCG, total E3, and maternal age.
Conclusion: Urine free β-hCG and total E3 are useful markers for Down syndrome screening during the second trimester in Taiwanese women.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin, beta Subunit, Human - urine</subject><subject>Down Syndrome - diagnosis</subject><subject>Estriol - urine</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Diagnosis - methods</subject><subject>Taiwan</subject><subject>Tropical medicine</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EotPCI4C8QKgsUvyXxF6haoAWqRILqMTOcpwbxuCxp3bCqG9fZzKi7FjYV7a-c4_vMUKvKLmghDbvvxHCVNVKIc6VekcIoaSiT9CKypZXjPMfT9HqL3KCTnP-NUON4s_RCSVcqpbJFRpvkwuAhwSAOxhNtVlfYRN6PMbReAx5TC56PMSEP8Z9wPk-9CluAWdbJMGFn7if0lzGTbkEG2dtctuihIRdKM3wZXZl38Xd5M3oYniBng3GZ3h5rGfo9vOn7-vr6ubr1Zf15U1lueS0Mox3lDELivOutZZ2VIDtulbwrlZ9rZQ1vBGCUzBiYIqS2tbCsoFwsDWz_Ay9XfruUrybyov01mUL3psAccq6UbLmrZQFrBfQpphzgkHvyggm3WtK9By3PsSt5yy1UvoQt6ZF9_poMHVb6P9RLfkW4M0RMNkaPyQTrMuPnGykOPiLBdtHX2LLv_20h6Q3YPy4md1Iw-ryv0op0pZTVRab7T8sMigh_nFFka2DYKF3Ceyo--j-M8ADgACsnQ</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Hsu, Jenn J</creator><creator>Hsu, Te Y</creator><creator>Hsieh, T’Sang T</creator><creator>Soong, Yung K</creator><creator>Hsieh, Fon J</creator><creator>Spencer, Kevin</creator><general>Elsevier Inc</general><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Urine free beta-hCG and total estriol for Down syndrome screening during the second trimester in an Asian population</title><author>Hsu, Jenn J ; Hsu, Te Y ; Hsieh, T’Sang T ; Soong, Yung K ; Hsieh, Fon J ; Spencer, Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3831-a23b122ce933b7cc1b14ecbb743b59d599ca364431ea4f29105c54c2f03ec52c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - urine</topic><topic>Down Syndrome - diagnosis</topic><topic>Estriol - urine</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Diagnosis - methods</topic><topic>Taiwan</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Jenn J</creatorcontrib><creatorcontrib>Hsu, Te Y</creatorcontrib><creatorcontrib>Hsieh, T’Sang T</creatorcontrib><creatorcontrib>Soong, Yung K</creatorcontrib><creatorcontrib>Hsieh, Fon J</creatorcontrib><creatorcontrib>Spencer, Kevin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Jenn J</au><au>Hsu, Te Y</au><au>Hsieh, T’Sang T</au><au>Soong, Yung K</au><au>Hsieh, Fon J</au><au>Spencer, Kevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urine free beta-hCG and total estriol for Down syndrome screening during the second trimester in an Asian population</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1999-07</date><risdate>1999</risdate><volume>94</volume><issue>1</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Objective: To evaluate second-trimester free β-hCG and total estriol (E3) in the maternal urine as markers for Down syndrome screening in an Asian population.
Methods: Free β-hCG and total E3 were measured in the urine samples of 28 Taiwanese Down syndrome pregnancies and 268 unaffected singleton pregnancies at 14–25 weeks. Results were normalized to urine creatinine concentrations and converted to multiples of the median (MoM) levels. Gestational ages were estimated by ultrasound measurements.
Results: Median values of free β-hCG, total E3, free β-hCG to total E3 ratio, and the free β-hCG to total E3 MoM ratio in Down syndrome pregnancies were 4.75 MoM, 0.66 MoM, 8.99 MoM, and 9.51, respectively. At a 5% false-positive rate, the observed detection rates were 36% (ten of 28) with total E3, 71% (20 of 28) with free β-hCG, 68% (19 of 28) with free β-hCG/total E3, and 71% (20 of 28) with free β-hCG/total E3 MoM. When combined with maternal age, the expected detection rates were 65% with total E3, 71% with free β-hCG, 76% with free β-hCG/total E3, 80% with free β-hCG/total E3 MoM, and 89% when combining free β-hCG, total E3, and maternal age.
Conclusion: Urine free β-hCG and total E3 are useful markers for Down syndrome screening during the second trimester in Taiwanese women.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10389728</pmid><doi>10.1016/S0029-7844(99)00010-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1999-07, Vol.94 (1), p.107-111 |
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| subjects | Adult Biological and medical sciences Chorionic Gonadotropin, beta Subunit, Human - urine Down Syndrome - diagnosis Estriol - urine Female Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Prenatal Diagnosis - methods Taiwan Tropical medicine |
| title | Urine free beta-hCG and total estriol for Down syndrome screening during the second trimester in an Asian population |
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