Hepatitis E infection in children: Study of an outbreak
Background : Hepatitis E virus (HEV) is responsible for most of the hepatitis epidemics in the developing world and it frequently affects young adults. Therefore, common perception is that it does not affect children. Methods : A group of 20 school children (13 years old) were possibly exposed to he...
Gespeichert in:
| Veröffentlicht in: | Journal of gastroenterology and hepatology 1999-06, Vol.14 (6), p.572-577 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 577 |
|---|---|
| container_issue | 6 |
| container_start_page | 572 |
| container_title | Journal of gastroenterology and hepatology |
| container_volume | 14 |
| creator | Arora, Narender Panda, Subrat Nanda, Santosh Ansari, Israrul Joshi, Seema Dixit, Rajesh Bathla, Rajni |
| description | Background
: Hepatitis E virus (HEV) is responsible for most of the hepatitis epidemics in the developing world and it frequently affects young adults. Therefore, common perception is that it does not affect children.
Methods
: A group of 20 school children (13 years old) were possibly exposed to hepatitis E virus infection during a 2 day trekking trip. Epidemiological and clinical information was correlated to the presence of the hepatitis E virus genome and antibodies to HEV structural and non‐structural proteins found in the blood of the children, using polymerase chain reaction and line immunoassay techniques.
Results
: Ten children developed icteric hepatitis, seven prodrome‐like illness without jaundice while three remained asymptomatic. Immunoglobulin M (IgM) antibodies to open reading frame (ORF)2 protein (pORF2) were detected in all 19 children tested, whereas 11 and 10 of the children were positive for IgM antibodies against ORF1 (pORF1) and ORF3 (pORF3) proteins, respectively. The rate of HEV infection was found to be 85%. Viraemia was observed in 11 children and was present in four of the seven anicteric patients (55%) compared with six of the nine (66%) icteric patients. One child without any symptom also had viraemia.
Conclusions
: The data obtained indicate a high susceptibility of children for HEV infection and a frequently prolonged viraemia in those infected.
© 1999 Blackwell Science Asia Pty Ltd |
| doi_str_mv | 10.1046/j.1440-1746.1999.01916.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69853194</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69853194</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4326-126e254624c9c585a39154ffc2139a43223ac29fee4c038101ba71bb7a3feee13</originalsourceid><addsrcrecordid>eNqNkEtP4zAUhS00CErhL6AsRrNL8I0fiUeaxaiCFlQB4iEkNpbjOsIlTYqdiPbf45CKmSUrX_l-x-f4IBQBTgBTfrZMgFIcQ0Z5AkKIBIMAnmz20Ohr8QONcA4sFgTEITryfokxpjhjB-gQMMkZ5tkIZTOzVq1trY_OI1uXRre2qcMU6RdbLZypf0f3bbfYRk0ZqTpqurZwRr0eo_1SVd6c7M4xerw4f5jM4vnN9HLydx5rSlIeQ8pNyihPqRaa5UwRAYyWpU6BCBWQlCiditIYqkMmwFCoDIoiUyTcGSBj9Gt4d-2at874Vq6s16aqVG2azksuchY-SAOYD6B2jffOlHLt7Eq5rQQs-9LkUvbdyL4b2ZcmP0uTmyA93Xl0xcos_hMOLQXg5w5QXquqdKrW1v_jchIM-qx_BuzdVmb7bX95NZ31U9DHg9761my-9Mq9yhAiY_Lpeir57fMVFjmXd-QDwJOUqA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69853194</pqid></control><display><type>article</type><title>Hepatitis E infection in children: Study of an outbreak</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Arora, Narender ; Panda, Subrat ; Nanda, Santosh ; Ansari, Israrul ; Joshi, Seema ; Dixit, Rajesh ; Bathla, Rajni</creator><creatorcontrib>Arora, Narender ; Panda, Subrat ; Nanda, Santosh ; Ansari, Israrul ; Joshi, Seema ; Dixit, Rajesh ; Bathla, Rajni</creatorcontrib><description>Background
: Hepatitis E virus (HEV) is responsible for most of the hepatitis epidemics in the developing world and it frequently affects young adults. Therefore, common perception is that it does not affect children.
Methods
: A group of 20 school children (13 years old) were possibly exposed to hepatitis E virus infection during a 2 day trekking trip. Epidemiological and clinical information was correlated to the presence of the hepatitis E virus genome and antibodies to HEV structural and non‐structural proteins found in the blood of the children, using polymerase chain reaction and line immunoassay techniques.
Results
: Ten children developed icteric hepatitis, seven prodrome‐like illness without jaundice while three remained asymptomatic. Immunoglobulin M (IgM) antibodies to open reading frame (ORF)2 protein (pORF2) were detected in all 19 children tested, whereas 11 and 10 of the children were positive for IgM antibodies against ORF1 (pORF1) and ORF3 (pORF3) proteins, respectively. The rate of HEV infection was found to be 85%. Viraemia was observed in 11 children and was present in four of the seven anicteric patients (55%) compared with six of the nine (66%) icteric patients. One child without any symptom also had viraemia.
Conclusions
: The data obtained indicate a high susceptibility of children for HEV infection and a frequently prolonged viraemia in those infected.
© 1999 Blackwell Science Asia Pty Ltd</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1046/j.1440-1746.1999.01916.x</identifier><identifier>PMID: 10385067</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Adolescent ; Antibodies, Viral - blood ; Biological and medical sciences ; Capsid - immunology ; Capsid Proteins ; children ; Cohort Studies ; Disease Outbreaks ; Electrophoresis, Agar Gel ; Female ; Glycoproteins - immunology ; Hepatitis E - epidemiology ; Hepatitis E - immunology ; Hepatitis E - virology ; hepatitis E virus ; Human viral diseases ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; India ; India - epidemiology ; Infectious diseases ; line immunoassay ; Male ; Medical sciences ; outbreak ; polymerase chain reaction ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - blood ; subclinical ; Tropical medicine ; Viral diseases ; Viral hepatitis ; Viremia - blood</subject><ispartof>Journal of gastroenterology and hepatology, 1999-06, Vol.14 (6), p.572-577</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4326-126e254624c9c585a39154ffc2139a43223ac29fee4c038101ba71bb7a3feee13</citedby><cites>FETCH-LOGICAL-c4326-126e254624c9c585a39154ffc2139a43223ac29fee4c038101ba71bb7a3feee13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1746.1999.01916.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1746.1999.01916.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1831041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10385067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arora, Narender</creatorcontrib><creatorcontrib>Panda, Subrat</creatorcontrib><creatorcontrib>Nanda, Santosh</creatorcontrib><creatorcontrib>Ansari, Israrul</creatorcontrib><creatorcontrib>Joshi, Seema</creatorcontrib><creatorcontrib>Dixit, Rajesh</creatorcontrib><creatorcontrib>Bathla, Rajni</creatorcontrib><title>Hepatitis E infection in children: Study of an outbreak</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background
: Hepatitis E virus (HEV) is responsible for most of the hepatitis epidemics in the developing world and it frequently affects young adults. Therefore, common perception is that it does not affect children.
Methods
: A group of 20 school children (13 years old) were possibly exposed to hepatitis E virus infection during a 2 day trekking trip. Epidemiological and clinical information was correlated to the presence of the hepatitis E virus genome and antibodies to HEV structural and non‐structural proteins found in the blood of the children, using polymerase chain reaction and line immunoassay techniques.
Results
: Ten children developed icteric hepatitis, seven prodrome‐like illness without jaundice while three remained asymptomatic. Immunoglobulin M (IgM) antibodies to open reading frame (ORF)2 protein (pORF2) were detected in all 19 children tested, whereas 11 and 10 of the children were positive for IgM antibodies against ORF1 (pORF1) and ORF3 (pORF3) proteins, respectively. The rate of HEV infection was found to be 85%. Viraemia was observed in 11 children and was present in four of the seven anicteric patients (55%) compared with six of the nine (66%) icteric patients. One child without any symptom also had viraemia.
Conclusions
: The data obtained indicate a high susceptibility of children for HEV infection and a frequently prolonged viraemia in those infected.
© 1999 Blackwell Science Asia Pty Ltd</description><subject>Adolescent</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Capsid - immunology</subject><subject>Capsid Proteins</subject><subject>children</subject><subject>Cohort Studies</subject><subject>Disease Outbreaks</subject><subject>Electrophoresis, Agar Gel</subject><subject>Female</subject><subject>Glycoproteins - immunology</subject><subject>Hepatitis E - epidemiology</subject><subject>Hepatitis E - immunology</subject><subject>Hepatitis E - virology</subject><subject>hepatitis E virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>India</subject><subject>India - epidemiology</subject><subject>Infectious diseases</subject><subject>line immunoassay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>outbreak</subject><subject>polymerase chain reaction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Viral - blood</subject><subject>subclinical</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viremia - blood</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtP4zAUhS00CErhL6AsRrNL8I0fiUeaxaiCFlQB4iEkNpbjOsIlTYqdiPbf45CKmSUrX_l-x-f4IBQBTgBTfrZMgFIcQ0Z5AkKIBIMAnmz20Ohr8QONcA4sFgTEITryfokxpjhjB-gQMMkZ5tkIZTOzVq1trY_OI1uXRre2qcMU6RdbLZypf0f3bbfYRk0ZqTpqurZwRr0eo_1SVd6c7M4xerw4f5jM4vnN9HLydx5rSlIeQ8pNyihPqRaa5UwRAYyWpU6BCBWQlCiditIYqkMmwFCoDIoiUyTcGSBj9Gt4d-2at874Vq6s16aqVG2azksuchY-SAOYD6B2jffOlHLt7Eq5rQQs-9LkUvbdyL4b2ZcmP0uTmyA93Xl0xcos_hMOLQXg5w5QXquqdKrW1v_jchIM-qx_BuzdVmb7bX95NZ31U9DHg9761my-9Mq9yhAiY_Lpeir57fMVFjmXd-QDwJOUqA</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Arora, Narender</creator><creator>Panda, Subrat</creator><creator>Nanda, Santosh</creator><creator>Ansari, Israrul</creator><creator>Joshi, Seema</creator><creator>Dixit, Rajesh</creator><creator>Bathla, Rajni</creator><general>Blackwell Science Pty</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199906</creationdate><title>Hepatitis E infection in children: Study of an outbreak</title><author>Arora, Narender ; Panda, Subrat ; Nanda, Santosh ; Ansari, Israrul ; Joshi, Seema ; Dixit, Rajesh ; Bathla, Rajni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4326-126e254624c9c585a39154ffc2139a43223ac29fee4c038101ba71bb7a3feee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Capsid - immunology</topic><topic>Capsid Proteins</topic><topic>children</topic><topic>Cohort Studies</topic><topic>Disease Outbreaks</topic><topic>Electrophoresis, Agar Gel</topic><topic>Female</topic><topic>Glycoproteins - immunology</topic><topic>Hepatitis E - epidemiology</topic><topic>Hepatitis E - immunology</topic><topic>Hepatitis E - virology</topic><topic>hepatitis E virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>India</topic><topic>India - epidemiology</topic><topic>Infectious diseases</topic><topic>line immunoassay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>outbreak</topic><topic>polymerase chain reaction</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Viral - blood</topic><topic>subclinical</topic><topic>Tropical medicine</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viremia - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arora, Narender</creatorcontrib><creatorcontrib>Panda, Subrat</creatorcontrib><creatorcontrib>Nanda, Santosh</creatorcontrib><creatorcontrib>Ansari, Israrul</creatorcontrib><creatorcontrib>Joshi, Seema</creatorcontrib><creatorcontrib>Dixit, Rajesh</creatorcontrib><creatorcontrib>Bathla, Rajni</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arora, Narender</au><au>Panda, Subrat</au><au>Nanda, Santosh</au><au>Ansari, Israrul</au><au>Joshi, Seema</au><au>Dixit, Rajesh</au><au>Bathla, Rajni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis E infection in children: Study of an outbreak</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>1999-06</date><risdate>1999</risdate><volume>14</volume><issue>6</issue><spage>572</spage><epage>577</epage><pages>572-577</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background
: Hepatitis E virus (HEV) is responsible for most of the hepatitis epidemics in the developing world and it frequently affects young adults. Therefore, common perception is that it does not affect children.
Methods
: A group of 20 school children (13 years old) were possibly exposed to hepatitis E virus infection during a 2 day trekking trip. Epidemiological and clinical information was correlated to the presence of the hepatitis E virus genome and antibodies to HEV structural and non‐structural proteins found in the blood of the children, using polymerase chain reaction and line immunoassay techniques.
Results
: Ten children developed icteric hepatitis, seven prodrome‐like illness without jaundice while three remained asymptomatic. Immunoglobulin M (IgM) antibodies to open reading frame (ORF)2 protein (pORF2) were detected in all 19 children tested, whereas 11 and 10 of the children were positive for IgM antibodies against ORF1 (pORF1) and ORF3 (pORF3) proteins, respectively. The rate of HEV infection was found to be 85%. Viraemia was observed in 11 children and was present in four of the seven anicteric patients (55%) compared with six of the nine (66%) icteric patients. One child without any symptom also had viraemia.
Conclusions
: The data obtained indicate a high susceptibility of children for HEV infection and a frequently prolonged viraemia in those infected.
© 1999 Blackwell Science Asia Pty Ltd</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>10385067</pmid><doi>10.1046/j.1440-1746.1999.01916.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0815-9319 |
| ispartof | Journal of gastroenterology and hepatology, 1999-06, Vol.14 (6), p.572-577 |
| issn | 0815-9319 1440-1746 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69853194 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adolescent Antibodies, Viral - blood Biological and medical sciences Capsid - immunology Capsid Proteins children Cohort Studies Disease Outbreaks Electrophoresis, Agar Gel Female Glycoproteins - immunology Hepatitis E - epidemiology Hepatitis E - immunology Hepatitis E - virology hepatitis E virus Human viral diseases Humans Immunoglobulin G - blood Immunoglobulin M - blood India India - epidemiology Infectious diseases line immunoassay Male Medical sciences outbreak polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - blood subclinical Tropical medicine Viral diseases Viral hepatitis Viremia - blood |
| title | Hepatitis E infection in children: Study of an outbreak |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T05%3A51%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatitis%20E%20infection%20in%20children:%20Study%20of%20an%20outbreak&rft.jtitle=Journal%20of%20gastroenterology%20and%20hepatology&rft.au=Arora,%20Narender&rft.date=1999-06&rft.volume=14&rft.issue=6&rft.spage=572&rft.epage=577&rft.pages=572-577&rft.issn=0815-9319&rft.eissn=1440-1746&rft_id=info:doi/10.1046/j.1440-1746.1999.01916.x&rft_dat=%3Cproquest_cross%3E69853194%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69853194&rft_id=info:pmid/10385067&rfr_iscdi=true |