Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors

Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1A...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-06, Vol.9 (11), p.1583-1586
Hauptverfasser:	CALDIROLA, P, CHOWDHURY, R, UNELIUS, L, MOHELL, N, HACKSELL, U, JOHANSSON, A. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Chromans - chemical synthesis Fibroblasts Humans Medical sciences Mice Models, Chemical Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Receptors, Dopamine D2 - agonists Serotonin Receptor Agonists - metabolism Serotoninergic system Structure-Activity Relationship
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