Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors
Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1A...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1999-06, Vol.9 (11), p.1583-1586 |
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| container_end_page | 1586 |
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| container_issue | 11 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 9 |
| creator | CALDIROLA, P CHOWDHURY, R UNELIUS, L MOHELL, N HACKSELL, U JOHANSSON, A. M |
| description | Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1A receptors whereas the affinity for D2A receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues. |
| doi_str_mv | 10.1016/S0960-894X(99)00232-2 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1583-1586 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Brain - metabolism Chromans - chemical synthesis Fibroblasts Humans Medical sciences Mice Models, Chemical Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Receptors, Dopamine D2 - agonists Serotonin Receptor Agonists - metabolism Serotoninergic system Structure-Activity Relationship |
| title | Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors |
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