Decrease of metastatic ability after selection for intravasating ability in Lewis lung carcinoma (3LL) cell line
The release of cancer cells from the primary site and penetration into blood vessels are obligatory preliminary steps for metastasis. To investigate the mechanism of such steps we isolated variant cells (designated as Int-3LL) possessing enhanced intravasating ability from Lewis lung carcinoma (3LL)...
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| Veröffentlicht in: | Cancer letters 1999-05, Vol.139 (1), p.105-108 |
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| container_start_page | 105 |
| container_title | Cancer letters |
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| creator | Ota, Takahide Maeda, Masayo Tatsuka, Masaaki Matsui, Takeshi Tanino, Mikio Tanaka, Takuji |
| description | The release of cancer cells from the primary site and penetration into blood vessels are obligatory preliminary steps for metastasis. To investigate the mechanism of such steps we isolated variant cells (designated as Int-3LL) possessing enhanced intravasating ability from Lewis lung carcinoma (3LL) cells by in vivo selection. In spite of the enhanced intravasating ability of Int-3LL, the spontaneous and experimental metastatic abilities of Int-3LL decreased significantly compared to parent cells. Such a cell line has never been reported so far. The matched pair of cell lines described in this report provides a useful system for investigating the primary steps of metastasis. |
| doi_str_mv | 10.1016/S0304-3835(99)00026-9 |
| format | Article |
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To investigate the mechanism of such steps we isolated variant cells (designated as Int-3LL) possessing enhanced intravasating ability from Lewis lung carcinoma (3LL) cells by in vivo selection. In spite of the enhanced intravasating ability of Int-3LL, the spontaneous and experimental metastatic abilities of Int-3LL decreased significantly compared to parent cells. Such a cell line has never been reported so far. 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To investigate the mechanism of such steps we isolated variant cells (designated as Int-3LL) possessing enhanced intravasating ability from Lewis lung carcinoma (3LL) cells by in vivo selection. In spite of the enhanced intravasating ability of Int-3LL, the spontaneous and experimental metastatic abilities of Int-3LL decreased significantly compared to parent cells. Such a cell line has never been reported so far. The matched pair of cell lines described in this report provides a useful system for investigating the primary steps of metastasis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Cancer</subject><subject>Carcinoma, Lewis Lung - pathology</subject><subject>Dissemination</subject><subject>Grants</subject><subject>Intravasation</subject><subject>Lewis lung carcinoma</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasm Metastasis</subject><subject>Neoplastic Cells, Circulating</subject><subject>Tumor cell</subject><subject>Tumor Cells, Cultured - metabolism</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9rFTEQB_Agin2t_glKQCntYXWySXaTk0j9CQse1HPI5k0kZTf7TLKV_vfm9T2qePEUGD4zTOZLyDMGrxiw7vVX4CAarri80PoSANqu0Q_Ihqm-bXqt4CHZ3JMTcprzdUVS9PIxOWEgQGlgG7J7hy6hzUgXT2csNhdbgqN2DFMot9T6golmnNCVsETql0RDLMne2Fxh_HEvQ6QD_gqZTmutOptciMts6QUfhkvqcJroFCI-IY-8nTI-Pb5n5PuH99-uPjXDl4-fr94OjRNKlPoDpnBErpj1o7NMeoFOjZ4zQMF7bEH6VvJOt7ITVvRKgh2BAVctON4LfkbOD3N3afm5Yi5mDnm_hY24rNl0WslWqK7CF__A62VNse5m2npMxtsOeFXyoFxack7ozS6F2aZbw8DsAzF3gZj9tY3W5i4Qo2vf8-P0dZxx-1fXIYEKXh6Bzc5OPtnoQv7jFAil93PeHBjWm90ETCa7gNHhNqQajdku4T-b_AZE1KYN</recordid><startdate>19990503</startdate><enddate>19990503</enddate><creator>Ota, Takahide</creator><creator>Maeda, Masayo</creator><creator>Tatsuka, Masaaki</creator><creator>Matsui, Takeshi</creator><creator>Tanino, Mikio</creator><creator>Tanaka, Takuji</creator><general>Elsevier B.V</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19990503</creationdate><title>Decrease of metastatic ability after selection for intravasating ability in Lewis lung carcinoma (3LL) cell line</title><author>Ota, Takahide ; Maeda, Masayo ; Tatsuka, Masaaki ; Matsui, Takeshi ; Tanino, Mikio ; Tanaka, Takuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-7918ebe381afbca15f4ec8bf310e437e205f253692564a47850ab0103820c3743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood vessels</topic><topic>Cancer</topic><topic>Carcinoma, Lewis Lung - pathology</topic><topic>Dissemination</topic><topic>Grants</topic><topic>Intravasation</topic><topic>Lewis lung carcinoma</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasm Metastasis</topic><topic>Neoplastic Cells, Circulating</topic><topic>Tumor cell</topic><topic>Tumor Cells, Cultured - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ota, Takahide</creatorcontrib><creatorcontrib>Maeda, Masayo</creatorcontrib><creatorcontrib>Tatsuka, Masaaki</creatorcontrib><creatorcontrib>Matsui, Takeshi</creatorcontrib><creatorcontrib>Tanino, Mikio</creatorcontrib><creatorcontrib>Tanaka, Takuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ota, Takahide</au><au>Maeda, Masayo</au><au>Tatsuka, Masaaki</au><au>Matsui, Takeshi</au><au>Tanino, Mikio</au><au>Tanaka, Takuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease of metastatic ability after selection for intravasating ability in Lewis lung carcinoma (3LL) cell line</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1999-05-03</date><risdate>1999</risdate><volume>139</volume><issue>1</issue><spage>105</spage><epage>108</epage><pages>105-108</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The release of cancer cells from the primary site and penetration into blood vessels are obligatory preliminary steps for metastasis. 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1999-05, Vol.139 (1), p.105-108 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Blood vessels Cancer Carcinoma, Lewis Lung - pathology Dissemination Grants Intravasation Lewis lung carcinoma Lung cancer Lung carcinoma Lungs Male Medical research Medical sciences Metastases Metastasis Mice Mice, Inbred C57BL Neoplasm Metastasis Neoplastic Cells, Circulating Tumor cell Tumor Cells, Cultured - metabolism Tumors |
| title | Decrease of metastatic ability after selection for intravasating ability in Lewis lung carcinoma (3LL) cell line |
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