CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes

The unconventional myosin Myo1c has been implicated in insulin-regulated GLUT4 translocation to the plasma membrane in adipocytes. We show that Myo1c undergoes insulin-dependent phosphorylation at S701. Phosphorylation was accompanied by enhanced 14-3-3 binding and reduced calmodulin binding. Recomb...

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Veröffentlicht in:	Cell metabolism 2008-11, Vol.8 (5), p.384-398
Hauptverfasser:	Yip, Ming Fai, Ramm, Georg, Larance, Mark, Hoehn, Kyle L., Wagner, Mark C., Guilhaus, Michael, James, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology 14-3-3 Proteins - metabolism Adipocytes - metabolism Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Cell Line Cricetinae Glucose Transporter Type 4 - metabolism HUMDISEASE Insulin - physiology Mice Myosin Type I Myosins - metabolism Phosphorylation Protein Transport SIGNALING SYSBIO
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