Identification of particulates in vaccine formulations containing aluminum phosphate

Abstract Density gradient centrifugation was used for identification of particulates in vaccines formulated with aluminum phosphate (AlPO4 ) adjuvant. Protein-derived particulates are sporadically seen in protein pre-filled formulations where siliconized syringes are employed. These particulates are...

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Veröffentlicht in:	Vaccine 2008-12, Vol.26 (52), p.6814-6817
Hauptverfasser:	Lin, Xi, Hudock, Hugh, Arumugham, Rasappa, Loun, Bounthon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry Allergy and Immunology Aluminum Aluminum Compounds - chemistry Aluminum Compounds - isolation & purification Aluminum phosphate adjuvant Applied microbiology Atoms & subatomic particles Biological and medical sciences Centrifugation Centrifugation, Density Gradient Chemistry, Pharmaceutical Density gradient centrifugation Diatrizoate Ficoll Fundamental and applied biological sciences. Psychology Microbiology Migration Particulate Matter - analysis Particulate Matter - isolation & purification Particulates Particulates in vaccine formulations Phosphates - chemistry Phosphates - isolation & purification Proteins Syringes Vaccines Vaccines - analysis Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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