Identification of particulates in vaccine formulations containing aluminum phosphate
Abstract Density gradient centrifugation was used for identification of particulates in vaccines formulated with aluminum phosphate (AlPO4 ) adjuvant. Protein-derived particulates are sporadically seen in protein pre-filled formulations where siliconized syringes are employed. These particulates are...
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| Veröffentlicht in: | Vaccine 2008-12, Vol.26 (52), p.6814-6817 |
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| creator | Lin, Xi Hudock, Hugh Arumugham, Rasappa Loun, Bounthon |
| description | Abstract Density gradient centrifugation was used for identification of particulates in vaccines formulated with aluminum phosphate (AlPO4 ) adjuvant. Protein-derived particulates are sporadically seen in protein pre-filled formulations where siliconized syringes are employed. These particulates are difficult to distinguish from the AlPO4 suspension. Prior to centrifugation, Histopaque solution is placed at the bottom of the test tube (or the original syringe), resulting in a layer beneath the suspension. After brief centrifugation, AlPO4 settles to the bottom of the test tube, while the light-weighted particulates in the sample become visible, floating in the inter-phase between the two layers. |
| doi_str_mv | 10.1016/j.vaccine.2008.09.090 |
| format | Article |
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Protein-derived particulates are sporadically seen in protein pre-filled formulations where siliconized syringes are employed. These particulates are difficult to distinguish from the AlPO4 suspension. Prior to centrifugation, Histopaque solution is placed at the bottom of the test tube (or the original syringe), resulting in a layer beneath the suspension. After brief centrifugation, AlPO4 settles to the bottom of the test tube, while the light-weighted particulates in the sample become visible, floating in the inter-phase between the two layers.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.09.090</identifier><identifier>PMID: 18950668</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - chemistry ; Allergy and Immunology ; Aluminum ; Aluminum Compounds - chemistry ; Aluminum Compounds - isolation & purification ; Aluminum phosphate adjuvant ; Applied microbiology ; Atoms & subatomic particles ; Biological and medical sciences ; Centrifugation ; Centrifugation, Density Gradient ; Chemistry, Pharmaceutical ; Density gradient centrifugation ; Diatrizoate ; Ficoll ; Fundamental and applied biological sciences. Psychology ; Microbiology ; Migration ; Particulate Matter - analysis ; Particulate Matter - isolation & purification ; Particulates ; Particulates in vaccine formulations ; Phosphates - chemistry ; Phosphates - isolation & purification ; Proteins ; Syringes ; Vaccines ; Vaccines - analysis ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2008-12, Vol.26 (52), p.6814-6817</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Elsevier Limited Dec 9, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-a2ee67b142dfce9c8f963eb7b653567c94b9e38a8d815e643976791d752b45913</citedby><cites>FETCH-LOGICAL-c507t-a2ee67b142dfce9c8f963eb7b653567c94b9e38a8d815e643976791d752b45913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1625840253?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20942857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18950668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Xi</creatorcontrib><creatorcontrib>Hudock, Hugh</creatorcontrib><creatorcontrib>Arumugham, Rasappa</creatorcontrib><creatorcontrib>Loun, Bounthon</creatorcontrib><title>Identification of particulates in vaccine formulations containing aluminum phosphate</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Density gradient centrifugation was used for identification of particulates in vaccines formulated with aluminum phosphate (AlPO4 ) adjuvant. Protein-derived particulates are sporadically seen in protein pre-filled formulations where siliconized syringes are employed. These particulates are difficult to distinguish from the AlPO4 suspension. Prior to centrifugation, Histopaque solution is placed at the bottom of the test tube (or the original syringe), resulting in a layer beneath the suspension. After brief centrifugation, AlPO4 settles to the bottom of the test tube, while the light-weighted particulates in the sample become visible, floating in the inter-phase between the two layers.</description><subject>Adjuvants, Immunologic - chemistry</subject><subject>Allergy and Immunology</subject><subject>Aluminum</subject><subject>Aluminum Compounds - chemistry</subject><subject>Aluminum Compounds - isolation & purification</subject><subject>Aluminum phosphate adjuvant</subject><subject>Applied microbiology</subject><subject>Atoms & subatomic particles</subject><subject>Biological and medical sciences</subject><subject>Centrifugation</subject><subject>Centrifugation, Density Gradient</subject><subject>Chemistry, Pharmaceutical</subject><subject>Density gradient centrifugation</subject><subject>Diatrizoate</subject><subject>Ficoll</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Microbiology</subject><subject>Migration</subject><subject>Particulate Matter - analysis</subject><subject>Particulate Matter - isolation & purification</subject><subject>Particulates</subject><subject>Particulates in vaccine formulations</subject><subject>Phosphates - chemistry</subject><subject>Phosphates - isolation & purification</subject><subject>Proteins</subject><subject>Syringes</subject><subject>Vaccines</subject><subject>Vaccines - analysis</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl9r1jAUxoMo7t30IygF0bu-niRNmtw4ZDgdDLxwgnchTU9dXtu0Ju1g396UtzjYzeBAIPzOc_48h5A3FPYUqPx42N9Z53zAPQNQe9A54BnZUVXzkgmqnpMdMFmVFYVfJ-Q0pQMACE71S3JClRYgpdqRm6sWw-w77-zsx1CMXTHZOHu39HbGVPhQbHWKbozD-puxVLgxzNYHH34Xtl8GH5ahmG7HNN3mtFfkRWf7hK-394z8vPxyc_GtvP7-9eri83XpBNRzaRmirBtasbZzqJ3qtOTY1I0UXMja6arRyJVVraICZcV1LWtN21qwphKa8jPy4ag7xfHvgmk2g08O-94GHJdkpFYCmGBPglTzGrTiGXz3CDyMSwx5CEMlE6rKcisljpSLY0oROzNFP9h4byiY1R1zMNvWzOqOAZ0Dct7bTX1pBmwfsjY7MvB-A2xytu-iDc6n_xwDXTEl6sydHznM273zGE1yHoPD1kd0s2lH_2Qrnx4puD7bmYv-wXtMD1ObxAyYH-sprZcECiiXleb_ACPyxRs</recordid><startdate>20081209</startdate><enddate>20081209</enddate><creator>Lin, Xi</creator><creator>Hudock, Hugh</creator><creator>Arumugham, Rasappa</creator><creator>Loun, Bounthon</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081209</creationdate><title>Identification of particulates in vaccine formulations containing aluminum phosphate</title><author>Lin, Xi ; Hudock, Hugh ; Arumugham, Rasappa ; Loun, Bounthon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-a2ee67b142dfce9c8f963eb7b653567c94b9e38a8d815e643976791d752b45913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adjuvants, Immunologic - chemistry</topic><topic>Allergy and Immunology</topic><topic>Aluminum</topic><topic>Aluminum Compounds - chemistry</topic><topic>Aluminum Compounds - isolation & purification</topic><topic>Aluminum phosphate adjuvant</topic><topic>Applied microbiology</topic><topic>Atoms & subatomic particles</topic><topic>Biological and medical sciences</topic><topic>Centrifugation</topic><topic>Centrifugation, Density Gradient</topic><topic>Chemistry, Pharmaceutical</topic><topic>Density gradient centrifugation</topic><topic>Diatrizoate</topic><topic>Ficoll</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Microbiology</topic><topic>Migration</topic><topic>Particulate Matter - analysis</topic><topic>Particulate Matter - isolation & purification</topic><topic>Particulates</topic><topic>Particulates in vaccine formulations</topic><topic>Phosphates - chemistry</topic><topic>Phosphates - isolation & purification</topic><topic>Proteins</topic><topic>Syringes</topic><topic>Vaccines</topic><topic>Vaccines - analysis</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Xi</creatorcontrib><creatorcontrib>Hudock, Hugh</creatorcontrib><creatorcontrib>Arumugham, Rasappa</creatorcontrib><creatorcontrib>Loun, Bounthon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Xi</au><au>Hudock, Hugh</au><au>Arumugham, Rasappa</au><au>Loun, Bounthon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of particulates in vaccine formulations containing aluminum phosphate</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2008-12-09</date><risdate>2008</risdate><volume>26</volume><issue>52</issue><spage>6814</spage><epage>6817</epage><pages>6814-6817</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract Density gradient centrifugation was used for identification of particulates in vaccines formulated with aluminum phosphate (AlPO4 ) adjuvant. Protein-derived particulates are sporadically seen in protein pre-filled formulations where siliconized syringes are employed. These particulates are difficult to distinguish from the AlPO4 suspension. Prior to centrifugation, Histopaque solution is placed at the bottom of the test tube (or the original syringe), resulting in a layer beneath the suspension. After brief centrifugation, AlPO4 settles to the bottom of the test tube, while the light-weighted particulates in the sample become visible, floating in the inter-phase between the two layers.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>18950668</pmid><doi>10.1016/j.vaccine.2008.09.090</doi><tpages>4</tpages></addata></record> |
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| ispartof | Vaccine, 2008-12, Vol.26 (52), p.6814-6817 |
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| subjects | Adjuvants, Immunologic - chemistry Allergy and Immunology Aluminum Aluminum Compounds - chemistry Aluminum Compounds - isolation & purification Aluminum phosphate adjuvant Applied microbiology Atoms & subatomic particles Biological and medical sciences Centrifugation Centrifugation, Density Gradient Chemistry, Pharmaceutical Density gradient centrifugation Diatrizoate Ficoll Fundamental and applied biological sciences. Psychology Microbiology Migration Particulate Matter - analysis Particulate Matter - isolation & purification Particulates Particulates in vaccine formulations Phosphates - chemistry Phosphates - isolation & purification Proteins Syringes Vaccines Vaccines - analysis Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Identification of particulates in vaccine formulations containing aluminum phosphate |
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