An early developmental role for Eph-ephrin interaction during vertebrate gastrulation

Eph receptor tyrosine kinases (RTK) and their ephrin ligands are involved in the transmission of signals which regulate cytoskeletal organisation and cell migration, and are expressed in spatially restricted patterns at discrete phases during embryogenesis. Loss of function mutants of Eph RTK or eph...

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Veröffentlicht in:	Mechanisms of development 1999-05, Vol.83 (1), p.77-94
Hauptverfasser:	Oates, Andrew C, Lackmann, Martin, Power, Mary-Anne, Brennan, Caroline, Down, L.Michelle, Do, Cuong, Evans, Betty, Holder, Nigel, Boyd, Andrew W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BIAcore analysis Boundary formation Cell Movement CNS patterning Danio rerio Development Dose-Response Relationship, Drug Embryo, Nonmammalian - anatomy & histology Eph EphA1 EphA3 EphB1 Ephrin Ephrin-A1 Ephrin-A3 Ephrin-A5 Ephrin-B1 Fc-fusion Gastrula - metabolism Gastrulation Gene Expression Regulation, Developmental Genes, Dominant HEK Humans Kinetics LERK-7 Membrane Proteins - analysis Membrane Proteins - metabolism Mesoderm Multigene Family - physiology Proteins - metabolism RNA microinjection RNA, Messenger - pharmacology Somitogenesis Time Factors Vertebrate embryogenesis Whole-mount in situ hybridisation Zebrafish Zebrafish - embryology
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