PCNA damage caused by antineoplastic drugs

Structurally diverse chemotherapeutic and chemopreventive drugs, including camptothecin, doxorubicin, sanguinarine, and others, were found to cause covalent crosslinking of proliferating cell nuclear antigen (PCNA) trimers in mammalian cells exposed to fluorescent light. This PCNA damage was caused...

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Veröffentlicht in:	Biochemical pharmacology 2008-12, Vol.76 (12), p.1653-1668
Hauptverfasser:	Bae, Soo In, Zhao, Ran, Snapka, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - adverse effects Biological and medical sciences Cell Line, Tumor Dimerization Histidine - metabolism Humans Large T antigen Light - adverse effects Medical sciences PCNA Pharmacology. Drug treatments Photochemistry Photodynamic Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism Protein crosslinks Protein damage Simian virus 40 Singlet Oxygen
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