HER-2 Gene Amplification, HER-2 and Epidermal Growth Factor Receptor mRNA and Protein Expression, and Lapatinib Efficacy in Women with Metastatic Breast Cancer

Purpose: Biomarkers from two randomized phase III trials were analyzed to optimize selection of patients for lapatinib therapy. Experimental Design: In available breast cancer tissue from EGF30001 (paclitaxel ± lapatinib in HER-2-negative/unknown metastatic breast cancer, n = 579) and EGF100151 (cap...

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Veröffentlicht in:	Clinical cancer research 2008-12, Vol.14 (23), p.7861-7870
Hauptverfasser:	PRESS, Michael F, FINN, Richard S, DANENBERG, Kathy, MARTIN, Anne Marie, WILLIAMS, Lisa, OLIVA, Cristina, STEIN, Steven, GAGNON, Robert, ARBUSHITES, Michael, KOEHLER, Maria T, CAMERON, David, DI LEO, Angelo, GEYER, Charles E, VILLALOBOS, Ivonne E, SANTIAGO, Angela, GUZMAN, Roberta, GASPARYAN, Armen, YANLING MA
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Biomarkers, Tumor - genetics Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Clinical Trials, Phase III as Topic Disease-Free Survival Drug Resistance, Neoplasm - genetics EGFR Female Gene Amplification Genes, erbB-2 Gynecology. Andrology. Obstetrics HER-2 Humans Immunohistochemistry In Situ Hybridization, Fluorescence - standards Kaplan-Meier Estimate Laboratories, Hospital - standards lapatinib Mammary gland diseases Medical Laboratory Personnel Medical sciences metastatic breast cancer Pathology, Clinical - standards Pharmacology. Drug treatments Physicians Quinazolines - therapeutic use Receptor, Epidermal Growth Factor - biosynthesis Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Tumors
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