The Role of Laminin-1 in the Modulation of Radiation Damage in Endothelial Cells and Differentiation

Microvascular dysfunction due to endothelial damage is often associated with the ionizing radiation used during cancer therapy. This radiation-induced capillary injury is a major factor in the inhibition of new vessel growth (angiogenesis) and in disease states such as radiation-induced pneumonitis...

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Veröffentlicht in:	Radiation research 1999-07, Vol.152 (1), p.14-28
Hauptverfasser:	Rose, R. Wesley, O'Hara, Michael D., Williamson, Shirnett K., Grant, Derrick S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Aorta, Abdominal Aorta, Thoracic Basement membrane Biological and medical sciences Cell Differentiation - radiation effects Cell Division - radiation effects Cell physiology Cells, Cultured Collagen Cultured cells DNA Fragmentation - radiation effects Drug Combinations Effects of physical and chemical agents Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - physiology Endothelium, Vascular - radiation effects Fundamental and applied biological sciences. Psychology Gamma Rays Gene Expression Regulation, Enzymologic - radiation effects Human umbilical vein endothelial cells Humans Irradiation Kinetics Laminin - pharmacology Laminin - physiology Molecular and cellular biology Neovascularization, Physiologic - radiation effects Organ Culture Techniques Proteoglycans Radiation damage Radiation dosage Radiation effects Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases - genetics Receptors Receptors, Growth Factor - genetics Receptors, Vascular Endothelial Growth Factor Space life sciences Time Factors Umbilical Veins
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