Diphtheria and tetanus toxoid microencapsulation into conventional and end-group alkylated PLA/PLGAs

The feasibility of biodegradable polyester microspheres (MS) for single injection vaccines will greatly depend on the toxoid stability within the MS exposed to in vivo conditions. This study examined the effects of polymer type and co-encapsulated additives on diphtheria (Dtxd) and tetanus (Ttxd) to...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 1999-05, Vol.47 (3), p.193-201
Hauptverfasser:	Johansen, Pål, Tamber, Harjit, Merkle, Hans P, Gander, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Additives Alkylation Antigen delivery Biocompatible Materials Biological and medical sciences Capsules Diphtheria toxoid Diphtheria Toxoid - administration & dosage Diphtheria Toxoid - analysis Drug Combinations Drug Stability Enzyme-Linked Immunosorbent Assay General pharmacology Injections Lactic Acid Loading estimation Medical sciences Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLA PLGA Polyglycolic Acid Polymers Serum Albumin, Bovine Stability Stearylated PLA Tetanus toxoid Tetanus Toxoid - administration & dosage Tetanus Toxoid - analysis Trehalose Vaccines
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