Hormonal regulation of microsomal cytochrome P4502E1 and P450 reductase in rat liver and kidney

1. The relative roles of pituitary hormones (especially growth hormone) and testicular hormones (especially testosterone) in the regulation of renal and hepatic CYP2E1 and cytochrome P450 reductase have been studied in the male rat. 2. Depletion of pituitary hormones by hypophysectomy (Hx) resulted...

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Veröffentlicht in:	Xenobiotica 1999, Vol.29 (5), p.437-451
Hauptverfasser:	CHEN, G.-F., RONIS, M. J. J., INGELMAN-SUNDBERG, M., BADGER, T. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Androgens - metabolism Animals Biological and medical sciences Cytochrome P-450 CYP2E1 - drug effects Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP2E1 - metabolism cytochrome P4502E1 Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Growth Hormone - metabolism Growth Hormone - pharmacology Hormones - metabolism Hormones - pharmacology Hypophysectomy Insulin-Like Growth Factor I - metabolism Kidney - drug effects Kidney - metabolism Male Medicin och hälsovetenskap Microsomes - drug effects Microsomes - metabolism Microsomes, Liver - drug effects Microsomes, Liver - metabolism NADH, NADPH Oxidoreductases - drug effects NADH, NADPH Oxidoreductases - metabolism NADP - metabolism NADPH-Ferrihemoprotein Reductase Orchiectomy Oxidoreductases Pituitary Gland - physiology Pituitary Gland - surgery Rats Rats, Sprague-Dawley reductase RNA, Messenger - metabolism Testosterone - blood Transcription, Genetic Weight Gain - drug effects
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