Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms
Multiple trauma leads to a deterioration of the immune system. On the one hand, hyperinflammation mediates remote organ damage and may lead to multi-organ failure. On the other hand, immunosuppression develops and promotes an enhanced risk to acquire infectious complications after trauma. The mechan...
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| Veröffentlicht in: | Innate Immunity 2008-12, Vol.14 (6), p.333-344 |
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| container_title | Innate Immunity |
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| creator | Flohé, Stefanie B. Flohé, Sascha Schade, F. Ulrich |
| description | Multiple trauma leads to a deterioration of the immune system. On the one hand, hyperinflammation mediates remote organ damage and may lead to multi-organ failure. On the other hand, immunosuppression develops and promotes an enhanced risk to acquire infectious complications after trauma. The mechanisms that underlie these opposing consequences of trauma are not yet completely understood. There is increasing evidence that endogenous danger signals that derive from destroyed tissues play a role in trauma-induced immune dysfunction. Here, we give an overview on the common animal models that are used to investigate trauma-induced pathology, potential signals and cellular mechanisms that support the imbalance between inflammation and counter-regulation after trauma. |
| doi_str_mv | 10.1177/1753425908100016 |
| format | Article |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Antigen Presentation Dendritic Cells - immunology Disease Models, Animal Heat-Shock Proteins - immunology HMGB1 Protein - immunology Humans Immune System - immunology Immune System - physiopathology Immunity, Cellular Immunity, Innate Macrophages - immunology Multiple Trauma - immunology Multiple Trauma - pathology Multiple Trauma - physiopathology Signal Transduction - immunology T-Lymphocyte Subsets - immunology Th1 Cells - immunology |
| title | Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms |
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