Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients
Some critically ill patients have difficulty in mobilizing their respiratory secretions. These patients can develop pulmonary atelectasis that may result in hypoxemia. There are some data to show that atelectasis may be prevented by turning a patient from side to side utilizing special beds. To dete...
Gespeichert in:
Veröffentlicht in: | Chest 1999-06, Vol.115 (6), p.1658-1666 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1666 |
---|---|
container_issue | 6 |
container_start_page | 1658 |
container_title | Chest |
container_volume | 115 |
creator | Raoof, Suhail Chowdhrey, Naseer Raoof, Sabiha Feuerman, Martin King, Alan Sriraman, Rajesh Khan, Faroque A. |
description | Some critically ill patients have difficulty in mobilizing their respiratory secretions. These patients can develop pulmonary atelectasis that may result in hypoxemia. There are some data to show that atelectasis may be prevented by turning a patient from side to side utilizing special beds.
To determine the role of kinetic therapy (KT) combined with mechanical percussion (P) in the resolution of established atelectasis of the lungs and hypoxemia in critically ill, hospitalized patients. (KT was defined as rotation of a patient along the longitudinal axis of ≥ 40° to each side continuously.)
Prospective and randomized study (2:1 test to control group).
Twenty-four patients with respiratory failure, either mechanically ventilated or spontaneously breathing, who demonstrated segmental, lobar, or unilateral entire lung atelectasis were studied.
Medical ICU and adult respiratory ward in a county hospital in New York.
Seventeen patients were treated with KT combined with mechanical P using a KT system (Triadyne Kinetic Therapy System; KCI; San Antonio, TX). Seven patients received manual repositioning and manual P every 2 h. Both groups received similar conventional therapy with inhaled bronchodilators and suctioning.
Partial or complete resolution of atelectasis was seen in 14 of 17 patients (82.3%) in the test group as compared with 1 of 7 patient (14.3%) in the control group. The median duration to resolution of atelectasis was 4 days in the test group. Bronchoscopy was performed in 3 of 7 patients in the control group, but in none of the patients in the test group. A cost of $720 was incurred per patient for utilizing the specialty beds for a mean duration of 4 days. An improvement in oxygenation index occurred in the test group (change in baseline Pao2/fraction of inspired oxygen from 207.4 ± 106.7 mm Hg to 318 ± 100.7 mm Hg) at the end of therapy, while the control group showed a reduction over a similar duration of time (181.3 ± 96.3 mm Hg to 112 ± 21.2 mm Hg).
KT and mechanical P therapy resulted in significantly greater partial or complete resolution of atelectasis as compared with conventional therapy. There was a generalized trend toward statistical significance in the improvement of oxygenation and a reduced need for bronchoscopy in the group receiving KT and P therapy. |
doi_str_mv | 10.1378/chest.115.6.1658 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69844094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0012369215383057</els_id><sourcerecordid>69844094</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-bdd6df6a836e163e722e89e95b6875a640871219ac1779ddbe7e75922111cd223</originalsourceid><addsrcrecordid>eNp1kUtv1DAUhS0EotPCnhWyWLDL4OskTsyuGpVSUYkKlbXl2DfElZMMtgOaf4-HjHhJbPw859PVOYS8ALaFsmnfmAFj2gLUW7EFUbePyAZkCUVZV-VjsmEMeFEKyc_IeYwPLN9BiqfkDFh216LekOWq79EkOvd0N4-dm9DSD3lNztD7AYPeH6ieLL3DYJYY3Tz9es7HNCD9hHH2Szr-ZMhlQp95OrpI3UR3wWWS9v5Ab7yndzo5nFJ8Rp702kd8ftovyOd3V_e798Xtx-ub3eVtYSqoUtFZK2wvdFsKBFFiwzm2EmXdibaptahY2wAHqQ00jbS2wwabWnIOAMZyXl6Q1yt3H-avS85KjS4a9F5POC9RCdlWFZNVFr76R_gwL2HKsynOWFUJxtssYqvIhDnGgL3aBzfqcFDA1LEP9bMPlftQQh37yJaXJ-7SjWj_MKwF_GYO7svw3QVUccxxZXm50k5z_MV8u1owJ_fNYVDR5FQN2mw3SdnZ_X-gHzpcrFo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200446028</pqid></control><display><type>article</type><title>Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Raoof, Suhail ; Chowdhrey, Naseer ; Raoof, Sabiha ; Feuerman, Martin ; King, Alan ; Sriraman, Rajesh ; Khan, Faroque A.</creator><creatorcontrib>Raoof, Suhail ; Chowdhrey, Naseer ; Raoof, Sabiha ; Feuerman, Martin ; King, Alan ; Sriraman, Rajesh ; Khan, Faroque A.</creatorcontrib><description>Some critically ill patients have difficulty in mobilizing their respiratory secretions. These patients can develop pulmonary atelectasis that may result in hypoxemia. There are some data to show that atelectasis may be prevented by turning a patient from side to side utilizing special beds.
To determine the role of kinetic therapy (KT) combined with mechanical percussion (P) in the resolution of established atelectasis of the lungs and hypoxemia in critically ill, hospitalized patients. (KT was defined as rotation of a patient along the longitudinal axis of ≥ 40° to each side continuously.)
Prospective and randomized study (2:1 test to control group).
Twenty-four patients with respiratory failure, either mechanically ventilated or spontaneously breathing, who demonstrated segmental, lobar, or unilateral entire lung atelectasis were studied.
Medical ICU and adult respiratory ward in a county hospital in New York.
Seventeen patients were treated with KT combined with mechanical P using a KT system (Triadyne Kinetic Therapy System; KCI; San Antonio, TX). Seven patients received manual repositioning and manual P every 2 h. Both groups received similar conventional therapy with inhaled bronchodilators and suctioning.
Partial or complete resolution of atelectasis was seen in 14 of 17 patients (82.3%) in the test group as compared with 1 of 7 patient (14.3%) in the control group. The median duration to resolution of atelectasis was 4 days in the test group. Bronchoscopy was performed in 3 of 7 patients in the control group, but in none of the patients in the test group. A cost of $720 was incurred per patient for utilizing the specialty beds for a mean duration of 4 days. An improvement in oxygenation index occurred in the test group (change in baseline Pao2/fraction of inspired oxygen from 207.4 ± 106.7 mm Hg to 318 ± 100.7 mm Hg) at the end of therapy, while the control group showed a reduction over a similar duration of time (181.3 ± 96.3 mm Hg to 112 ± 21.2 mm Hg).
KT and mechanical P therapy resulted in significantly greater partial or complete resolution of atelectasis as compared with conventional therapy. There was a generalized trend toward statistical significance in the improvement of oxygenation and a reduced need for bronchoscopy in the group receiving KT and P therapy.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.115.6.1658</identifier><identifier>PMID: 10378565</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; atelectasis ; Blood Gas Analysis ; Bronchoscopy - economics ; Cost-Benefit Analysis ; Critical Illness ; Female ; Follow-Up Studies ; Humans ; kinetic therapy ; Length of Stay ; Male ; oxygenation ; Percussion ; Physical Therapy Modalities - economics ; Physical Therapy Modalities - methods ; Prospective Studies ; Pulmonary Atelectasis - blood ; Pulmonary Atelectasis - diagnosis ; Pulmonary Atelectasis - therapy ; Radiography, Thoracic ; Rotation ; Treatment Outcome</subject><ispartof>Chest, 1999-06, Vol.115 (6), p.1658-1666</ispartof><rights>1999 The American College of Chest Physicians</rights><rights>Copyright American College of Chest Physicians Jun 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-bdd6df6a836e163e722e89e95b6875a640871219ac1779ddbe7e75922111cd223</citedby><cites>FETCH-LOGICAL-c414t-bdd6df6a836e163e722e89e95b6875a640871219ac1779ddbe7e75922111cd223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10378565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raoof, Suhail</creatorcontrib><creatorcontrib>Chowdhrey, Naseer</creatorcontrib><creatorcontrib>Raoof, Sabiha</creatorcontrib><creatorcontrib>Feuerman, Martin</creatorcontrib><creatorcontrib>King, Alan</creatorcontrib><creatorcontrib>Sriraman, Rajesh</creatorcontrib><creatorcontrib>Khan, Faroque A.</creatorcontrib><title>Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients</title><title>Chest</title><addtitle>Chest</addtitle><description>Some critically ill patients have difficulty in mobilizing their respiratory secretions. These patients can develop pulmonary atelectasis that may result in hypoxemia. There are some data to show that atelectasis may be prevented by turning a patient from side to side utilizing special beds.
To determine the role of kinetic therapy (KT) combined with mechanical percussion (P) in the resolution of established atelectasis of the lungs and hypoxemia in critically ill, hospitalized patients. (KT was defined as rotation of a patient along the longitudinal axis of ≥ 40° to each side continuously.)
Prospective and randomized study (2:1 test to control group).
Twenty-four patients with respiratory failure, either mechanically ventilated or spontaneously breathing, who demonstrated segmental, lobar, or unilateral entire lung atelectasis were studied.
Medical ICU and adult respiratory ward in a county hospital in New York.
Seventeen patients were treated with KT combined with mechanical P using a KT system (Triadyne Kinetic Therapy System; KCI; San Antonio, TX). Seven patients received manual repositioning and manual P every 2 h. Both groups received similar conventional therapy with inhaled bronchodilators and suctioning.
Partial or complete resolution of atelectasis was seen in 14 of 17 patients (82.3%) in the test group as compared with 1 of 7 patient (14.3%) in the control group. The median duration to resolution of atelectasis was 4 days in the test group. Bronchoscopy was performed in 3 of 7 patients in the control group, but in none of the patients in the test group. A cost of $720 was incurred per patient for utilizing the specialty beds for a mean duration of 4 days. An improvement in oxygenation index occurred in the test group (change in baseline Pao2/fraction of inspired oxygen from 207.4 ± 106.7 mm Hg to 318 ± 100.7 mm Hg) at the end of therapy, while the control group showed a reduction over a similar duration of time (181.3 ± 96.3 mm Hg to 112 ± 21.2 mm Hg).
KT and mechanical P therapy resulted in significantly greater partial or complete resolution of atelectasis as compared with conventional therapy. There was a generalized trend toward statistical significance in the improvement of oxygenation and a reduced need for bronchoscopy in the group receiving KT and P therapy.</description><subject>Aged</subject><subject>atelectasis</subject><subject>Blood Gas Analysis</subject><subject>Bronchoscopy - economics</subject><subject>Cost-Benefit Analysis</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>kinetic therapy</subject><subject>Length of Stay</subject><subject>Male</subject><subject>oxygenation</subject><subject>Percussion</subject><subject>Physical Therapy Modalities - economics</subject><subject>Physical Therapy Modalities - methods</subject><subject>Prospective Studies</subject><subject>Pulmonary Atelectasis - blood</subject><subject>Pulmonary Atelectasis - diagnosis</subject><subject>Pulmonary Atelectasis - therapy</subject><subject>Radiography, Thoracic</subject><subject>Rotation</subject><subject>Treatment Outcome</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtv1DAUhS0EotPCnhWyWLDL4OskTsyuGpVSUYkKlbXl2DfElZMMtgOaf4-HjHhJbPw859PVOYS8ALaFsmnfmAFj2gLUW7EFUbePyAZkCUVZV-VjsmEMeFEKyc_IeYwPLN9BiqfkDFh216LekOWq79EkOvd0N4-dm9DSD3lNztD7AYPeH6ieLL3DYJYY3Tz9es7HNCD9hHH2Szr-ZMhlQp95OrpI3UR3wWWS9v5Ab7yndzo5nFJ8Rp702kd8ftovyOd3V_e798Xtx-ub3eVtYSqoUtFZK2wvdFsKBFFiwzm2EmXdibaptahY2wAHqQ00jbS2wwabWnIOAMZyXl6Q1yt3H-avS85KjS4a9F5POC9RCdlWFZNVFr76R_gwL2HKsynOWFUJxtssYqvIhDnGgL3aBzfqcFDA1LEP9bMPlftQQh37yJaXJ-7SjWj_MKwF_GYO7svw3QVUccxxZXm50k5z_MV8u1owJ_fNYVDR5FQN2mw3SdnZ_X-gHzpcrFo</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Raoof, Suhail</creator><creator>Chowdhrey, Naseer</creator><creator>Raoof, Sabiha</creator><creator>Feuerman, Martin</creator><creator>King, Alan</creator><creator>Sriraman, Rajesh</creator><creator>Khan, Faroque A.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients</title><author>Raoof, Suhail ; Chowdhrey, Naseer ; Raoof, Sabiha ; Feuerman, Martin ; King, Alan ; Sriraman, Rajesh ; Khan, Faroque A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-bdd6df6a836e163e722e89e95b6875a640871219ac1779ddbe7e75922111cd223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>atelectasis</topic><topic>Blood Gas Analysis</topic><topic>Bronchoscopy - economics</topic><topic>Cost-Benefit Analysis</topic><topic>Critical Illness</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>kinetic therapy</topic><topic>Length of Stay</topic><topic>Male</topic><topic>oxygenation</topic><topic>Percussion</topic><topic>Physical Therapy Modalities - economics</topic><topic>Physical Therapy Modalities - methods</topic><topic>Prospective Studies</topic><topic>Pulmonary Atelectasis - blood</topic><topic>Pulmonary Atelectasis - diagnosis</topic><topic>Pulmonary Atelectasis - therapy</topic><topic>Radiography, Thoracic</topic><topic>Rotation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raoof, Suhail</creatorcontrib><creatorcontrib>Chowdhrey, Naseer</creatorcontrib><creatorcontrib>Raoof, Sabiha</creatorcontrib><creatorcontrib>Feuerman, Martin</creatorcontrib><creatorcontrib>King, Alan</creatorcontrib><creatorcontrib>Sriraman, Rajesh</creatorcontrib><creatorcontrib>Khan, Faroque A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raoof, Suhail</au><au>Chowdhrey, Naseer</au><au>Raoof, Sabiha</au><au>Feuerman, Martin</au><au>King, Alan</au><au>Sriraman, Rajesh</au><au>Khan, Faroque A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>115</volume><issue>6</issue><spage>1658</spage><epage>1666</epage><pages>1658-1666</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Some critically ill patients have difficulty in mobilizing their respiratory secretions. These patients can develop pulmonary atelectasis that may result in hypoxemia. There are some data to show that atelectasis may be prevented by turning a patient from side to side utilizing special beds.
To determine the role of kinetic therapy (KT) combined with mechanical percussion (P) in the resolution of established atelectasis of the lungs and hypoxemia in critically ill, hospitalized patients. (KT was defined as rotation of a patient along the longitudinal axis of ≥ 40° to each side continuously.)
Prospective and randomized study (2:1 test to control group).
Twenty-four patients with respiratory failure, either mechanically ventilated or spontaneously breathing, who demonstrated segmental, lobar, or unilateral entire lung atelectasis were studied.
Medical ICU and adult respiratory ward in a county hospital in New York.
Seventeen patients were treated with KT combined with mechanical P using a KT system (Triadyne Kinetic Therapy System; KCI; San Antonio, TX). Seven patients received manual repositioning and manual P every 2 h. Both groups received similar conventional therapy with inhaled bronchodilators and suctioning.
Partial or complete resolution of atelectasis was seen in 14 of 17 patients (82.3%) in the test group as compared with 1 of 7 patient (14.3%) in the control group. The median duration to resolution of atelectasis was 4 days in the test group. Bronchoscopy was performed in 3 of 7 patients in the control group, but in none of the patients in the test group. A cost of $720 was incurred per patient for utilizing the specialty beds for a mean duration of 4 days. An improvement in oxygenation index occurred in the test group (change in baseline Pao2/fraction of inspired oxygen from 207.4 ± 106.7 mm Hg to 318 ± 100.7 mm Hg) at the end of therapy, while the control group showed a reduction over a similar duration of time (181.3 ± 96.3 mm Hg to 112 ± 21.2 mm Hg).
KT and mechanical P therapy resulted in significantly greater partial or complete resolution of atelectasis as compared with conventional therapy. There was a generalized trend toward statistical significance in the improvement of oxygenation and a reduced need for bronchoscopy in the group receiving KT and P therapy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10378565</pmid><doi>10.1378/chest.115.6.1658</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0012-3692 |
ispartof | Chest, 1999-06, Vol.115 (6), p.1658-1666 |
issn | 0012-3692 1931-3543 |
language | eng |
recordid | cdi_proquest_miscellaneous_69844094 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | Aged atelectasis Blood Gas Analysis Bronchoscopy - economics Cost-Benefit Analysis Critical Illness Female Follow-Up Studies Humans kinetic therapy Length of Stay Male oxygenation Percussion Physical Therapy Modalities - economics Physical Therapy Modalities - methods Prospective Studies Pulmonary Atelectasis - blood Pulmonary Atelectasis - diagnosis Pulmonary Atelectasis - therapy Radiography, Thoracic Rotation Treatment Outcome |
title | Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T17%3A32%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Combined%20Kinetic%20Therapy%20and%20Percussion%20Therapy%20on%20the%20Resolution%20of%20Atelectasis%20in%20Critically%20Ill%20Patients&rft.jtitle=Chest&rft.au=Raoof,%20Suhail&rft.date=1999-06-01&rft.volume=115&rft.issue=6&rft.spage=1658&rft.epage=1666&rft.pages=1658-1666&rft.issn=0012-3692&rft.eissn=1931-3543&rft.coden=CHETBF&rft_id=info:doi/10.1378/chest.115.6.1658&rft_dat=%3Cproquest_cross%3E69844094%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=200446028&rft_id=info:pmid/10378565&rft_els_id=S0012369215383057&rfr_iscdi=true |