Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis
Semaphorins are major regulators of morphogenesis and are involved in a variety of processes ranging from the guidance of cell migration to the development of cancer. Since semaphorins were first characterized as repulsive neuronal guidance cues, their expression has been best documented in the nerv...
Gespeichert in:
| Veröffentlicht in: | Developmental dynamics 2008-12, Vol.237 (12), p.3853-3863 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3863 |
|---|---|
| container_issue | 12 |
| container_start_page | 3853 |
| container_title | Developmental dynamics |
| container_volume | 237 |
| creator | Koestner, Ulrich Shnitsar, Iryna Linnemannstöns, Karen Hufton, Andrew L. Borchers, Annette |
| description | Semaphorins are major regulators of morphogenesis and are involved in a variety of processes ranging from the guidance of cell migration to the development of cancer. Since semaphorins were first characterized as repulsive neuronal guidance cues, their expression has been best documented in the nervous system. However, broader studies are lacking. Here, we describe the expression of 13 members of the semaphorin family and two neuropilin receptors during early Xenopus laevis development. No particular expression pattern defines any of the semaphorin classes, but many are dynamically expressed in distinct areas undergoing morphogenetic cell movements like the developing mesoderm and the migrating neural crest. Furthermore, the complementary expression patterns of Sema3A/Nrp1 and Sema3F/Nrp2 are maintained across hundreds of millions of years, possibly indicating a conserved role in the guidance of migrating neural crest cells. Developmental Dynamics 237:3853–3863, 2008. © 2008 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.21785 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69843097</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21073981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4605-a12f6bdb912ca8f8ae33e1a7bc8f962644ae69428bf95adff92a747b2c8e27993</originalsourceid><addsrcrecordid>eNqFkLtOwzAUQC0EolBY-ADkiQEpxXYetkfU8pIqIcRDMFlOcl2MkjjYpNC_JyWV2GDyte65ZzgIHVEyoYSws3JZriaMcpFuoT1KJI8I5Xx7PaciErEQI7QfwhshRGQJ3UUjKqRIeUr20N091Lp9dd42WDclbqDzrrVV_4Wv1kMI1jW47Pr9AoP21QrXzvcHC2gg2ICdwc_QuLYLuNKwtOEA7RhdBTjcvGP0eHnxML2O5rdXN9PzeVQkGUkjTZnJ8jKXlBVaGKEhjoFqnhfCyIxlSaIhkwkTuZGpLo2RTPOE56wQwLiU8RidDN7Wu_cOwoeqbSigqnQDrgsqkyKJ-xj_gowSHktBe_B0AAvvQvBgVOttrf1KUaLWpdW6tPop3cPHG2uX11D-opu0PUAH4NNWsPpDpWZPs5dB-g0ZqYrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21073981</pqid></control><display><type>article</type><title>Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Alma/SFX Local Collection</source><creator>Koestner, Ulrich ; Shnitsar, Iryna ; Linnemannstöns, Karen ; Hufton, Andrew L. ; Borchers, Annette</creator><creatorcontrib>Koestner, Ulrich ; Shnitsar, Iryna ; Linnemannstöns, Karen ; Hufton, Andrew L. ; Borchers, Annette</creatorcontrib><description>Semaphorins are major regulators of morphogenesis and are involved in a variety of processes ranging from the guidance of cell migration to the development of cancer. Since semaphorins were first characterized as repulsive neuronal guidance cues, their expression has been best documented in the nervous system. However, broader studies are lacking. Here, we describe the expression of 13 members of the semaphorin family and two neuropilin receptors during early Xenopus laevis development. No particular expression pattern defines any of the semaphorin classes, but many are dynamically expressed in distinct areas undergoing morphogenetic cell movements like the developing mesoderm and the migrating neural crest. Furthermore, the complementary expression patterns of Sema3A/Nrp1 and Sema3F/Nrp2 are maintained across hundreds of millions of years, possibly indicating a conserved role in the guidance of migrating neural crest cells. Developmental Dynamics 237:3853–3863, 2008. © 2008 Wiley‐Liss, Inc.</description><identifier>ISSN: 1058-8388</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.21785</identifier><identifier>PMID: 18985750</identifier><language>eng</language><publisher>New York: Wiley‐Liss, Inc</publisher><subject>Animals ; Cells, Cultured ; convergent extension ; Embryo, Nonmammalian - embryology ; Embryo, Nonmammalian - metabolism ; Freshwater ; Gene Expression Regulation, Developmental ; Humans ; Mesoderm - embryology ; Mesoderm - metabolism ; Morphogenesis ; neural crest ; Neural Crest - embryology ; Neural Crest - metabolism ; neuropilin ; Neuropilins - genetics ; Neuropilins - metabolism ; Phylogeny ; semaphorin ; Semaphorins - genetics ; Semaphorins - metabolism ; Time Factors ; Xenopus ; Xenopus laevis ; Xenopus laevis - embryology ; Xenopus laevis - genetics ; Xenopus laevis - metabolism</subject><ispartof>Developmental dynamics, 2008-12, Vol.237 (12), p.3853-3863</ispartof><rights>Copyright © 2008 Wiley‐Liss, Inc.</rights><rights>(c) 2008 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4605-a12f6bdb912ca8f8ae33e1a7bc8f962644ae69428bf95adff92a747b2c8e27993</citedby><cites>FETCH-LOGICAL-c4605-a12f6bdb912ca8f8ae33e1a7bc8f962644ae69428bf95adff92a747b2c8e27993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdvdy.21785$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdvdy.21785$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18985750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koestner, Ulrich</creatorcontrib><creatorcontrib>Shnitsar, Iryna</creatorcontrib><creatorcontrib>Linnemannstöns, Karen</creatorcontrib><creatorcontrib>Hufton, Andrew L.</creatorcontrib><creatorcontrib>Borchers, Annette</creatorcontrib><title>Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>Semaphorins are major regulators of morphogenesis and are involved in a variety of processes ranging from the guidance of cell migration to the development of cancer. Since semaphorins were first characterized as repulsive neuronal guidance cues, their expression has been best documented in the nervous system. However, broader studies are lacking. Here, we describe the expression of 13 members of the semaphorin family and two neuropilin receptors during early Xenopus laevis development. No particular expression pattern defines any of the semaphorin classes, but many are dynamically expressed in distinct areas undergoing morphogenetic cell movements like the developing mesoderm and the migrating neural crest. Furthermore, the complementary expression patterns of Sema3A/Nrp1 and Sema3F/Nrp2 are maintained across hundreds of millions of years, possibly indicating a conserved role in the guidance of migrating neural crest cells. Developmental Dynamics 237:3853–3863, 2008. © 2008 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Cells, Cultured</subject><subject>convergent extension</subject><subject>Embryo, Nonmammalian - embryology</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Freshwater</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Humans</subject><subject>Mesoderm - embryology</subject><subject>Mesoderm - metabolism</subject><subject>Morphogenesis</subject><subject>neural crest</subject><subject>Neural Crest - embryology</subject><subject>Neural Crest - metabolism</subject><subject>neuropilin</subject><subject>Neuropilins - genetics</subject><subject>Neuropilins - metabolism</subject><subject>Phylogeny</subject><subject>semaphorin</subject><subject>Semaphorins - genetics</subject><subject>Semaphorins - metabolism</subject><subject>Time Factors</subject><subject>Xenopus</subject><subject>Xenopus laevis</subject><subject>Xenopus laevis - embryology</subject><subject>Xenopus laevis - genetics</subject><subject>Xenopus laevis - metabolism</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUQC0EolBY-ADkiQEpxXYetkfU8pIqIcRDMFlOcl2MkjjYpNC_JyWV2GDyte65ZzgIHVEyoYSws3JZriaMcpFuoT1KJI8I5Xx7PaciErEQI7QfwhshRGQJ3UUjKqRIeUr20N091Lp9dd42WDclbqDzrrVV_4Wv1kMI1jW47Pr9AoP21QrXzvcHC2gg2ICdwc_QuLYLuNKwtOEA7RhdBTjcvGP0eHnxML2O5rdXN9PzeVQkGUkjTZnJ8jKXlBVaGKEhjoFqnhfCyIxlSaIhkwkTuZGpLo2RTPOE56wQwLiU8RidDN7Wu_cOwoeqbSigqnQDrgsqkyKJ-xj_gowSHktBe_B0AAvvQvBgVOttrf1KUaLWpdW6tPop3cPHG2uX11D-opu0PUAH4NNWsPpDpWZPs5dB-g0ZqYrg</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Koestner, Ulrich</creator><creator>Shnitsar, Iryna</creator><creator>Linnemannstöns, Karen</creator><creator>Hufton, Andrew L.</creator><creator>Borchers, Annette</creator><general>Wiley‐Liss, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis</title><author>Koestner, Ulrich ; Shnitsar, Iryna ; Linnemannstöns, Karen ; Hufton, Andrew L. ; Borchers, Annette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4605-a12f6bdb912ca8f8ae33e1a7bc8f962644ae69428bf95adff92a747b2c8e27993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Cells, Cultured</topic><topic>convergent extension</topic><topic>Embryo, Nonmammalian - embryology</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>Freshwater</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Humans</topic><topic>Mesoderm - embryology</topic><topic>Mesoderm - metabolism</topic><topic>Morphogenesis</topic><topic>neural crest</topic><topic>Neural Crest - embryology</topic><topic>Neural Crest - metabolism</topic><topic>neuropilin</topic><topic>Neuropilins - genetics</topic><topic>Neuropilins - metabolism</topic><topic>Phylogeny</topic><topic>semaphorin</topic><topic>Semaphorins - genetics</topic><topic>Semaphorins - metabolism</topic><topic>Time Factors</topic><topic>Xenopus</topic><topic>Xenopus laevis</topic><topic>Xenopus laevis - embryology</topic><topic>Xenopus laevis - genetics</topic><topic>Xenopus laevis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koestner, Ulrich</creatorcontrib><creatorcontrib>Shnitsar, Iryna</creatorcontrib><creatorcontrib>Linnemannstöns, Karen</creatorcontrib><creatorcontrib>Hufton, Andrew L.</creatorcontrib><creatorcontrib>Borchers, Annette</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koestner, Ulrich</au><au>Shnitsar, Iryna</au><au>Linnemannstöns, Karen</au><au>Hufton, Andrew L.</au><au>Borchers, Annette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2008-12</date><risdate>2008</risdate><volume>237</volume><issue>12</issue><spage>3853</spage><epage>3863</epage><pages>3853-3863</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>Semaphorins are major regulators of morphogenesis and are involved in a variety of processes ranging from the guidance of cell migration to the development of cancer. Since semaphorins were first characterized as repulsive neuronal guidance cues, their expression has been best documented in the nervous system. However, broader studies are lacking. Here, we describe the expression of 13 members of the semaphorin family and two neuropilin receptors during early Xenopus laevis development. No particular expression pattern defines any of the semaphorin classes, but many are dynamically expressed in distinct areas undergoing morphogenetic cell movements like the developing mesoderm and the migrating neural crest. Furthermore, the complementary expression patterns of Sema3A/Nrp1 and Sema3F/Nrp2 are maintained across hundreds of millions of years, possibly indicating a conserved role in the guidance of migrating neural crest cells. Developmental Dynamics 237:3853–3863, 2008. © 2008 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley‐Liss, Inc</pub><pmid>18985750</pmid><doi>10.1002/dvdy.21785</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-8388 |
| ispartof | Developmental dynamics, 2008-12, Vol.237 (12), p.3853-3863 |
| issn | 1058-8388 1097-0177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69843097 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Animals Cells, Cultured convergent extension Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Freshwater Gene Expression Regulation, Developmental Humans Mesoderm - embryology Mesoderm - metabolism Morphogenesis neural crest Neural Crest - embryology Neural Crest - metabolism neuropilin Neuropilins - genetics Neuropilins - metabolism Phylogeny semaphorin Semaphorins - genetics Semaphorins - metabolism Time Factors Xenopus Xenopus laevis Xenopus laevis - embryology Xenopus laevis - genetics Xenopus laevis - metabolism |
| title | Semaphorin and neuropilin expression during early morphogenesis of Xenopus laevis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T13%3A28%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Semaphorin%20and%20neuropilin%20expression%20during%20early%20morphogenesis%20of%20Xenopus%20laevis&rft.jtitle=Developmental%20dynamics&rft.au=Koestner,%20Ulrich&rft.date=2008-12&rft.volume=237&rft.issue=12&rft.spage=3853&rft.epage=3863&rft.pages=3853-3863&rft.issn=1058-8388&rft.eissn=1097-0177&rft_id=info:doi/10.1002/dvdy.21785&rft_dat=%3Cproquest_cross%3E21073981%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21073981&rft_id=info:pmid/18985750&rfr_iscdi=true |