Retinochoroiditis is Induced by Oral Administration of Toxoplasma Gondii Cysts in the Hamster Model
Administration of Toxoplasma cysts by intraperitoneal innoculation in the Syrian Golden Hamster provides a reproducible animal model of acquired Toxoplasmic retinochoroiditis and cysts are observed in the brain. However, toxoplasmosis is frequently acquired by oral ingestion of contaminated foodstuf...
Gespeichert in:
| Veröffentlicht in: | Experimental eye research 1999-06, Vol.68 (6), p.657-661 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 661 |
|---|---|
| container_issue | 6 |
| container_start_page | 657 |
| container_title | Experimental eye research |
| container_volume | 68 |
| creator | GORMLEY, P.D. PAVESIO, C.E. LUTHERT, P. LIGHTMAN, S. |
| description | Administration of Toxoplasma cysts by intraperitoneal innoculation in the Syrian Golden Hamster provides a reproducible animal model of acquired Toxoplasmic retinochoroiditis and cysts are observed in the brain. However, toxoplasmosis is frequently acquired by oral ingestion of contaminated foodstuffs and it is recognised that the route by which disease is acquired may influence its pathogenesis and clinical expression. This study aimed to determine whether retinochorioiditis and cysts in the brain develop after oral ingestion in the Syrian Golden Hamster model as this is the route of induction akin to that in man and may therefore be more relevant in the study of disease pathogenesis. All animals developed disease by 4 weeks. Ocular and cerebral inflammation was confirmed by histology at 16 weeks and this was milder than in the original model. |
| doi_str_mv | 10.1006/exer.1998.0655 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69840853</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014483598906558</els_id><sourcerecordid>69840853</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-aa8b2068b4802a4cecf3836315815ef02e2a6b5c00f93a68fcd2ec14883fa4ee3</originalsourceid><addsrcrecordid>eNp1kEFr3DAQRkVpaTZJrz0WHUpv3owsWSsfw9ImgZRASc5ClsZExZa2krZk_31kdqG5FAYGhvfNDI-QzwzWDEBe4QumNet7tQbZde_IikEvGwDYvCcrACYaoXh3Rs5z_l2nXGzER3LGgG860aoVsb-w-BDtc0zRO198prXugttbdHQ40IdkJnrtZh98LskUHwONI32ML3E3mTwbehOD855uD7nUcKDlGemtmXPBRH9Gh9Ml-TCaKeOnU78gTz--P25vm_uHm7vt9X1juexLY4waWpBqEApaIyzakSsuOesU63CEFlsjh84CjD03Uo3WtWiZUIqPRiDyC_LtuHeX4p895qJnny1OkwkY91nLXglQHa_g-gjaFHNOOOpd8rNJB81AL1r1olUvWvWitQa-nDbvhxndG_zosQJfT4DJ1kxjMsH6_I_rQW3YclgdMawa_vp6I1uPoar2CW3RLvr_vfAKEkiUmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69840853</pqid></control><display><type>article</type><title>Retinochoroiditis is Induced by Oral Administration of Toxoplasma Gondii Cysts in the Hamster Model</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>GORMLEY, P.D. ; PAVESIO, C.E. ; LUTHERT, P. ; LIGHTMAN, S.</creator><creatorcontrib>GORMLEY, P.D. ; PAVESIO, C.E. ; LUTHERT, P. ; LIGHTMAN, S.</creatorcontrib><description>Administration of Toxoplasma cysts by intraperitoneal innoculation in the Syrian Golden Hamster provides a reproducible animal model of acquired Toxoplasmic retinochoroiditis and cysts are observed in the brain. However, toxoplasmosis is frequently acquired by oral ingestion of contaminated foodstuffs and it is recognised that the route by which disease is acquired may influence its pathogenesis and clinical expression. This study aimed to determine whether retinochorioiditis and cysts in the brain develop after oral ingestion in the Syrian Golden Hamster model as this is the route of induction akin to that in man and may therefore be more relevant in the study of disease pathogenesis. All animals developed disease by 4 weeks. Ocular and cerebral inflammation was confirmed by histology at 16 weeks and this was milder than in the original model.</description><identifier>ISSN: 0014-4835</identifier><identifier>EISSN: 1096-0007</identifier><identifier>DOI: 10.1006/exer.1998.0655</identifier><identifier>PMID: 10375428</identifier><identifier>CODEN: EXERA6</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Choroiditis - parasitology ; Cricetinae ; Disease Models, Animal ; Female ; Fundus Oculi ; Medical sciences ; Mesocricetus ; Miscellaneous ; Ophthalmology ; oral induction ; Retinitis - parasitology ; Retinitis - pathology ; retinochoroiditis ; Syrian Golden Hamster ; Toxoplasma gondii ; Toxoplasmosis, Ocular - pathology ; Toxoplasmosis, Ocular - transmission</subject><ispartof>Experimental eye research, 1999-06, Vol.68 (6), p.657-661</ispartof><rights>1999 Academic Press</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-aa8b2068b4802a4cecf3836315815ef02e2a6b5c00f93a68fcd2ec14883fa4ee3</citedby><cites>FETCH-LOGICAL-c369t-aa8b2068b4802a4cecf3836315815ef02e2a6b5c00f93a68fcd2ec14883fa4ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/exer.1998.0655$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1908713$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10375428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GORMLEY, P.D.</creatorcontrib><creatorcontrib>PAVESIO, C.E.</creatorcontrib><creatorcontrib>LUTHERT, P.</creatorcontrib><creatorcontrib>LIGHTMAN, S.</creatorcontrib><title>Retinochoroiditis is Induced by Oral Administration of Toxoplasma Gondii Cysts in the Hamster Model</title><title>Experimental eye research</title><addtitle>Exp Eye Res</addtitle><description>Administration of Toxoplasma cysts by intraperitoneal innoculation in the Syrian Golden Hamster provides a reproducible animal model of acquired Toxoplasmic retinochoroiditis and cysts are observed in the brain. However, toxoplasmosis is frequently acquired by oral ingestion of contaminated foodstuffs and it is recognised that the route by which disease is acquired may influence its pathogenesis and clinical expression. This study aimed to determine whether retinochorioiditis and cysts in the brain develop after oral ingestion in the Syrian Golden Hamster model as this is the route of induction akin to that in man and may therefore be more relevant in the study of disease pathogenesis. All animals developed disease by 4 weeks. Ocular and cerebral inflammation was confirmed by histology at 16 weeks and this was milder than in the original model.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choroiditis - parasitology</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundus Oculi</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>oral induction</subject><subject>Retinitis - parasitology</subject><subject>Retinitis - pathology</subject><subject>retinochoroiditis</subject><subject>Syrian Golden Hamster</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis, Ocular - pathology</subject><subject>Toxoplasmosis, Ocular - transmission</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFr3DAQRkVpaTZJrz0WHUpv3owsWSsfw9ImgZRASc5ClsZExZa2krZk_31kdqG5FAYGhvfNDI-QzwzWDEBe4QumNet7tQbZde_IikEvGwDYvCcrACYaoXh3Rs5z_l2nXGzER3LGgG860aoVsb-w-BDtc0zRO198prXugttbdHQ40IdkJnrtZh98LskUHwONI32ML3E3mTwbehOD855uD7nUcKDlGemtmXPBRH9Gh9Ml-TCaKeOnU78gTz--P25vm_uHm7vt9X1juexLY4waWpBqEApaIyzakSsuOesU63CEFlsjh84CjD03Uo3WtWiZUIqPRiDyC_LtuHeX4p895qJnny1OkwkY91nLXglQHa_g-gjaFHNOOOpd8rNJB81AL1r1olUvWvWitQa-nDbvhxndG_zosQJfT4DJ1kxjMsH6_I_rQW3YclgdMawa_vp6I1uPoar2CW3RLvr_vfAKEkiUmg</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>GORMLEY, P.D.</creator><creator>PAVESIO, C.E.</creator><creator>LUTHERT, P.</creator><creator>LIGHTMAN, S.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Retinochoroiditis is Induced by Oral Administration of Toxoplasma Gondii Cysts in the Hamster Model</title><author>GORMLEY, P.D. ; PAVESIO, C.E. ; LUTHERT, P. ; LIGHTMAN, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-aa8b2068b4802a4cecf3836315815ef02e2a6b5c00f93a68fcd2ec14883fa4ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Choroiditis - parasitology</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundus Oculi</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>oral induction</topic><topic>Retinitis - parasitology</topic><topic>Retinitis - pathology</topic><topic>retinochoroiditis</topic><topic>Syrian Golden Hamster</topic><topic>Toxoplasma gondii</topic><topic>Toxoplasmosis, Ocular - pathology</topic><topic>Toxoplasmosis, Ocular - transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GORMLEY, P.D.</creatorcontrib><creatorcontrib>PAVESIO, C.E.</creatorcontrib><creatorcontrib>LUTHERT, P.</creatorcontrib><creatorcontrib>LIGHTMAN, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GORMLEY, P.D.</au><au>PAVESIO, C.E.</au><au>LUTHERT, P.</au><au>LIGHTMAN, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinochoroiditis is Induced by Oral Administration of Toxoplasma Gondii Cysts in the Hamster Model</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>68</volume><issue>6</issue><spage>657</spage><epage>661</epage><pages>657-661</pages><issn>0014-4835</issn><eissn>1096-0007</eissn><coden>EXERA6</coden><abstract>Administration of Toxoplasma cysts by intraperitoneal innoculation in the Syrian Golden Hamster provides a reproducible animal model of acquired Toxoplasmic retinochoroiditis and cysts are observed in the brain. However, toxoplasmosis is frequently acquired by oral ingestion of contaminated foodstuffs and it is recognised that the route by which disease is acquired may influence its pathogenesis and clinical expression. This study aimed to determine whether retinochorioiditis and cysts in the brain develop after oral ingestion in the Syrian Golden Hamster model as this is the route of induction akin to that in man and may therefore be more relevant in the study of disease pathogenesis. All animals developed disease by 4 weeks. Ocular and cerebral inflammation was confirmed by histology at 16 weeks and this was milder than in the original model.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>10375428</pmid><doi>10.1006/exer.1998.0655</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4835 |
| ispartof | Experimental eye research, 1999-06, Vol.68 (6), p.657-661 |
| issn | 0014-4835 1096-0007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69840853 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Animals Biological and medical sciences Choroiditis - parasitology Cricetinae Disease Models, Animal Female Fundus Oculi Medical sciences Mesocricetus Miscellaneous Ophthalmology oral induction Retinitis - parasitology Retinitis - pathology retinochoroiditis Syrian Golden Hamster Toxoplasma gondii Toxoplasmosis, Ocular - pathology Toxoplasmosis, Ocular - transmission |
| title | Retinochoroiditis is Induced by Oral Administration of Toxoplasma Gondii Cysts in the Hamster Model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A21%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinochoroiditis%20is%20Induced%20by%20Oral%20Administration%20of%20Toxoplasma%20Gondii%20Cysts%20in%20the%20Hamster%20Model&rft.jtitle=Experimental%20eye%20research&rft.au=GORMLEY,%20P.D.&rft.date=1999-06-01&rft.volume=68&rft.issue=6&rft.spage=657&rft.epage=661&rft.pages=657-661&rft.issn=0014-4835&rft.eissn=1096-0007&rft.coden=EXERA6&rft_id=info:doi/10.1006/exer.1998.0655&rft_dat=%3Cproquest_cross%3E69840853%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69840853&rft_id=info:pmid/10375428&rft_els_id=S0014483598906558&rfr_iscdi=true |