Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine

It has been postulated that behavioral sensitization to cocaine is associated with an attenuation of cocaine-induced dopamine (DA) transmission in the medial prefrontal cortex (mPFC). Hence, experiments were designed to examine the effects of chemically-induced cortical DA depletion on the acute beh...

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Veröffentlicht in:	Brain research 1999-07, Vol.833 (2), p.133-141
Hauptverfasser:	Beyer, Chad E., Steketee, Jeffery D.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - analysis 6-Hydroxydopamine Animals Behavior, Animal - drug effects Biological and medical sciences Brain Chemistry - drug effects Chromatography, High Pressure Liquid Cocaine Cocaine - pharmacology Dopamine Dopamine - analysis Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug addictions Drug Tolerance Homovanillic Acid - analysis Hydroxyindoleacetic Acid - analysis Male Medial prefrontal cortex Medical sciences Microdialysis Nucleus accumbens Nucleus Accumbens - chemistry Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Oxidopamine Prefrontal Cortex - chemistry Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Sensitization Sympatholytics Synaptic Transmission - drug effects Toxicology
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