Brain Noradrenergic Receptors in Major Depression and Schizophrenia
The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann’s area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as fro...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 1999-07, Vol.21 (1), p.69-81 |
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| container_title | Neuropsychopharmacology (New York, N.Y.) |
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| creator | Klimek, Violetta Rajkowska, Graz·yna Luker, Stephen N Dilley, Ginny Meltzer, Herbert Y Overholser, James C Stockmeier, Craig A Ordway, Gregory A |
| description | The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann’s area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (−13 to −27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia. |
| doi_str_mv | 10.1016/S0893-133X(98)00134-1 |
| format | Article |
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No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (−13 to −27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(98)00134-1</identifier><identifier>PMID: 10379521</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenergic alpha-Agonists ; Adrenergic beta-Antagonists ; Adult ; Adult and adolescent clinical studies ; Affinity Labels ; Aged ; Autoradiography ; Biological and medical sciences ; Brain Chemistry - physiology ; Clonidine - analogs & derivatives ; Depression ; Depressive Disorder - metabolism ; Female ; Hippocampus ; Hippocampus - metabolism ; Humans ; Iodine Radioisotopes ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Noradrenergic receptors ; Norepinephrine - metabolism ; Pindolol - analogs & derivatives ; Postmortem ; Prefrontal cortex ; Prefrontal Cortex - metabolism ; Psychology. 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Psychiatry ; Psychoses ; Receptors, Adrenergic - metabolism ; Schizophrenia ; Schizophrenia - metabolism ; Suicide</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 1999-07, Vol.21 (1), p.69-81</ispartof><rights>1999 American College of Neuropsychopharmacology</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-6f93d9b2b2c6939abc11631fbf893e2ecc106a82cd8cfba872100ffaa613afb03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1804404$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10379521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klimek, Violetta</creatorcontrib><creatorcontrib>Rajkowska, Graz·yna</creatorcontrib><creatorcontrib>Luker, Stephen N</creatorcontrib><creatorcontrib>Dilley, Ginny</creatorcontrib><creatorcontrib>Meltzer, Herbert Y</creatorcontrib><creatorcontrib>Overholser, James C</creatorcontrib><creatorcontrib>Stockmeier, Craig A</creatorcontrib><creatorcontrib>Ordway, Gregory A</creatorcontrib><title>Brain Noradrenergic Receptors in Major Depression and Schizophrenia</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann’s area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (−13 to −27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia.</description><subject>Adrenergic alpha-Agonists</subject><subject>Adrenergic beta-Antagonists</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affinity Labels</subject><subject>Aged</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - physiology</subject><subject>Clonidine - analogs & derivatives</subject><subject>Depression</subject><subject>Depressive Disorder - metabolism</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Noradrenergic receptors</subject><subject>Norepinephrine - metabolism</subject><subject>Pindolol - analogs & derivatives</subject><subject>Postmortem</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Receptors, Adrenergic - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - metabolism</subject><subject>Suicide</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFOGzEQhi3UCkLKI4D2UFX0sK293jj2CZVQKBK0EgEpN2t2dgxGyXqxE6T26TEkAm49jUbzzcyvj7F9wb8JLtT3KddGlkLK2aHRXzkXsi7FFhuIcc1LJevZBzZ4RXbYbkr3GRqNld5mO4LLsRlVYsAmxxF8V_wOEdpIHcVbj8UVIfXLEFORR5dwH2JxQn2klHzoCujaYop3_l_o7_KKh0_so4N5or1NHbKb05_Xk1_lxZ-z88mPixJHXC5L5YxsTVM1FSojDTQohJLCNS7HpIoQBVegK2w1ugb0uBKcOweghATXcDlkX9Z3-xgeVpSWduET0nwOHYVVssromstKZ3C0BjGGlCI520e_gPjXCm6f7dkXe_ZZjTXavtjL3ZAdbB6smgW177bWujLweQNAQpi7CB369MZpXte8ztjRGqNs49FTtAk9dUitj4RL2wb_nyRP3qSMlw</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Klimek, Violetta</creator><creator>Rajkowska, Graz·yna</creator><creator>Luker, Stephen N</creator><creator>Dilley, Ginny</creator><creator>Meltzer, Herbert Y</creator><creator>Overholser, James C</creator><creator>Stockmeier, Craig A</creator><creator>Ordway, Gregory A</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Brain Noradrenergic Receptors in Major Depression and Schizophrenia</title><author>Klimek, Violetta ; Rajkowska, Graz·yna ; Luker, Stephen N ; Dilley, Ginny ; Meltzer, Herbert Y ; Overholser, James C ; Stockmeier, Craig A ; Ordway, Gregory A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-6f93d9b2b2c6939abc11631fbf893e2ecc106a82cd8cfba872100ffaa613afb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenergic alpha-Agonists</topic><topic>Adrenergic beta-Antagonists</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affinity Labels</topic><topic>Aged</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - physiology</topic><topic>Clonidine - analogs & derivatives</topic><topic>Depression</topic><topic>Depressive Disorder - metabolism</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Noradrenergic receptors</topic><topic>Norepinephrine - metabolism</topic><topic>Pindolol - analogs & derivatives</topic><topic>Postmortem</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Receptors, Adrenergic - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - metabolism</topic><topic>Suicide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klimek, Violetta</creatorcontrib><creatorcontrib>Rajkowska, Graz·yna</creatorcontrib><creatorcontrib>Luker, Stephen N</creatorcontrib><creatorcontrib>Dilley, Ginny</creatorcontrib><creatorcontrib>Meltzer, Herbert Y</creatorcontrib><creatorcontrib>Overholser, James C</creatorcontrib><creatorcontrib>Stockmeier, Craig A</creatorcontrib><creatorcontrib>Ordway, Gregory A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klimek, Violetta</au><au>Rajkowska, Graz·yna</au><au>Luker, Stephen N</au><au>Dilley, Ginny</au><au>Meltzer, Herbert Y</au><au>Overholser, James C</au><au>Stockmeier, Craig A</au><au>Ordway, Gregory A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Noradrenergic Receptors in Major Depression and Schizophrenia</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>21</volume><issue>1</issue><spage>69</spage><epage>81</epage><pages>69-81</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann’s area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (−13 to −27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10379521</pmid><doi>10.1016/S0893-133X(98)00134-1</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic alpha-Agonists Adrenergic beta-Antagonists Adult Adult and adolescent clinical studies Affinity Labels Aged Autoradiography Biological and medical sciences Brain Chemistry - physiology Clonidine - analogs & derivatives Depression Depressive Disorder - metabolism Female Hippocampus Hippocampus - metabolism Humans Iodine Radioisotopes Male Medical sciences Middle Aged Mood disorders Noradrenergic receptors Norepinephrine - metabolism Pindolol - analogs & derivatives Postmortem Prefrontal cortex Prefrontal Cortex - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, Adrenergic - metabolism Schizophrenia Schizophrenia - metabolism Suicide |
| title | Brain Noradrenergic Receptors in Major Depression and Schizophrenia |
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