Calcium and increase excitability promote tolerance against anoxia in hippocampal slices

We have previously demonstrated that anoxic preconditioning (APC) protects against a subsequent otherwise `lethal' anoxic insult in hippocampal slices. Tested here are two hypotheses: (a) APC requires calcium to improve electrical recovery in hippocampal slices; and (b) mild excitation promotes...

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Veröffentlicht in:	Brain research 1999-06, Vol.833 (1), p.20-26
Hauptverfasser:	Pérez-Pinzón, Miguel A., Born, James G., Centeno, José M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Adenosine Animals Anoxia Biological and medical sciences Calcium - physiology Central nervous system Conditioning (Psychology) - physiology Cortical Spreading Depression - physiology Electrophysiology Evoked Potentials - drug effects Evoked Potentials - physiology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiopathology Hypoxia - physiopathology In Vitro Techniques Ischemia Male Potassium Chloride - pharmacology Rats Rats, Wistar Tolerance Vertebrates: nervous system and sense organs Xanthines - pharmacology
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