Multifocality as a prognostic factor in breast cancer patients registered in Danish Breast Cancer Cooperative Group (DBCG) 1996–2001
Abstract The purpose of this study was to investigate the prognostic influence of multifocality in breast cancer patients. In a cohort of 7196 patients there were 945 patients with multifocality. We found no prognostic influence of multifocality on overall survival when controlling for known prognos...
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| Veröffentlicht in: | Breast (Edinburgh) 2008-12, Vol.17 (6), p.587-591 |
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| creator | Joergensen, L.E Gunnarsdottir, K.A Lanng, C Moeller, S Rasmussen, B.B |
| description | Abstract The purpose of this study was to investigate the prognostic influence of multifocality in breast cancer patients. In a cohort of 7196 patients there were 945 patients with multifocality. We found no prognostic influence of multifocality on overall survival when controlling for known prognostic factors. We found a small but significant influence on disease-free survival (HR = 1.16 [1.03–1.31]) and a strong correlation between multifocality and known prognostic factors. This was in accordance with an earlier study done on a smaller population and in a different period of time [Pedersen L, Gunnarsdottir KA, Rasmussen BB, Moeller S, Lanng C. The prognostic influence of multifocality in breast cancer patients. Breast 2004; 13 :188–193]. |
| doi_str_mv | 10.1016/j.breast.2008.06.004 |
| format | Article |
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In a cohort of 7196 patients there were 945 patients with multifocality. We found no prognostic influence of multifocality on overall survival when controlling for known prognostic factors. We found a small but significant influence on disease-free survival (HR = 1.16 [1.03–1.31]) and a strong correlation between multifocality and known prognostic factors. This was in accordance with an earlier study done on a smaller population and in a different period of time [Pedersen L, Gunnarsdottir KA, Rasmussen BB, Moeller S, Lanng C. The prognostic influence of multifocality in breast cancer patients. 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In a cohort of 7196 patients there were 945 patients with multifocality. We found no prognostic influence of multifocality on overall survival when controlling for known prognostic factors. We found a small but significant influence on disease-free survival (HR = 1.16 [1.03–1.31]) and a strong correlation between multifocality and known prognostic factors. This was in accordance with an earlier study done on a smaller population and in a different period of time [Pedersen L, Gunnarsdottir KA, Rasmussen BB, Moeller S, Lanng C. The prognostic influence of multifocality in breast cancer patients. Breast 2004; 13 :188–193].</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - mortality</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>Denmark - epidemiology</subject><subject>Disease-free survival</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Multifocality</subject><subject>Multivariate Analysis</subject><subject>Neoplasms, Multiple Primary - diagnosis</subject><subject>Neoplasms, Multiple Primary - mortality</subject><subject>Overall survival</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><issn>0960-9776</issn><issn>1532-3080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQhyMEokvhDRDyCcEhyzh_HPuC1KZlQSriUO6W44yLl2wcbKfS3jjxArwhT1JHWQmJCydfvpnxfPPLspcUthQoe7ffdh5ViNsCgG-BbQGqR9mG1mWRl8DhcbYBwSAXTcPOsmch7AFAlIw_zc4oZ4Jy3myyX5_nIVrjtBpsPBIViCKTd3ejC9FqYpSOzhM7knUY0WrU6MmkosUxBuLxzoaIHvsFulKjDd_I5cq2K9s6N6FPBfdIdt7NE3lzddnu3hIqBPvz83f6P32ePTFqCPji9J5ntx-uv7Yf85svu0_txU2uK1rHvCq4aRg0lWFl0fHalHXTFF1vlGGdAa5Ez7RAVvOyqVmDvKIFmK6oSzC9Ls-z12vXtOGPGUOUBxs0DoMa0c1BMsFLwalIYLWC2rsQPBo5eXtQ_igpyMW-3MtViFzsS2Ay2U9lr0795-6A_d-ik-4EvF8BTDveW_Qy6ORRY2896ih7Z_834d8GerCjTdf7jkcMezf7MfmTVIZCgrxdErAEIOUBUjKa8gH9lK1V</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Joergensen, L.E</creator><creator>Gunnarsdottir, K.A</creator><creator>Lanng, C</creator><creator>Moeller, S</creator><creator>Rasmussen, B.B</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Multifocality as a prognostic factor in breast cancer patients registered in Danish Breast Cancer Cooperative Group (DBCG) 1996–2001</title><author>Joergensen, L.E ; Gunnarsdottir, K.A ; Lanng, C ; Moeller, S ; Rasmussen, B.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-428f76074f632b85f35772bdfaf6bf08a9d6c9e65837567e84120fb2530fdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - mortality</topic><topic>Chi-Square Distribution</topic><topic>Cohort Studies</topic><topic>Denmark - epidemiology</topic><topic>Disease-free survival</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Multifocality</topic><topic>Multivariate Analysis</topic><topic>Neoplasms, Multiple Primary - diagnosis</topic><topic>Neoplasms, Multiple Primary - mortality</topic><topic>Overall survival</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joergensen, L.E</creatorcontrib><creatorcontrib>Gunnarsdottir, K.A</creatorcontrib><creatorcontrib>Lanng, C</creatorcontrib><creatorcontrib>Moeller, S</creatorcontrib><creatorcontrib>Rasmussen, B.B</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joergensen, L.E</au><au>Gunnarsdottir, K.A</au><au>Lanng, C</au><au>Moeller, S</au><au>Rasmussen, B.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifocality as a prognostic factor in breast cancer patients registered in Danish Breast Cancer Cooperative Group (DBCG) 1996–2001</atitle><jtitle>Breast (Edinburgh)</jtitle><addtitle>Breast</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>17</volume><issue>6</issue><spage>587</spage><epage>591</epage><pages>587-591</pages><issn>0960-9776</issn><eissn>1532-3080</eissn><abstract>Abstract The purpose of this study was to investigate the prognostic influence of multifocality in breast cancer patients. 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| ispartof | Breast (Edinburgh), 2008-12, Vol.17 (6), p.587-591 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Distribution Aged Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - mortality Chi-Square Distribution Cohort Studies Denmark - epidemiology Disease-free survival Female Hematology, Oncology and Palliative Medicine Humans Menopause Middle Aged Multifocality Multivariate Analysis Neoplasms, Multiple Primary - diagnosis Neoplasms, Multiple Primary - mortality Overall survival Prognosis Proportional Hazards Models Registries Retrospective Studies Survival Analysis |
| title | Multifocality as a prognostic factor in breast cancer patients registered in Danish Breast Cancer Cooperative Group (DBCG) 1996–2001 |
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