Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma
Prostaglandin D(2) (PGD(2)) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the identification of DP (DP1, PTGDR) and CRTH2 (DP2), two PGD(2)-specific transmembrane receptors with...
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| Veröffentlicht in: | Allergology international 2008-12, Vol.57 (4), p.307-312 |
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| creator | Oguma, Tsuyoshi Asano, Koichiro Ishizaka, Akitoshi |
| description | Prostaglandin D(2) (PGD(2)) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the identification of DP (DP1, PTGDR) and CRTH2 (DP2), two PGD(2)-specific transmembrane receptors with different distribution and intracellular signaling. Pharmacological tools, such as receptor-specific agonists and antagonists, and genetically-engineered mice, which lack either DP or CRTH2, have helped understand the complex effects of PGD(2) in allergic inflammation of the airways. Furthermore, genetic association studies have shown a positive linkage of the genetic polymorphisms in DP and CRTH2, with asthma phenotypes from specific ethnic backgrounds, further highlighting the importance of PGD(2) and its receptors in the pathophysiology of asthma. |
| doi_str_mv | 10.2332/allergolint.08-RAI-0033 |
| format | Article |
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However, little was known of the role it plays in the pathophysiology of asthma, until the identification of DP (DP1, PTGDR) and CRTH2 (DP2), two PGD(2)-specific transmembrane receptors with different distribution and intracellular signaling. Pharmacological tools, such as receptor-specific agonists and antagonists, and genetically-engineered mice, which lack either DP or CRTH2, have helped understand the complex effects of PGD(2) in allergic inflammation of the airways. 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Furthermore, genetic association studies have shown a positive linkage of the genetic polymorphisms in DP and CRTH2, with asthma phenotypes from specific ethnic backgrounds, further highlighting the importance of PGD(2) and its receptors in the pathophysiology of asthma.</description><subject>Animals</subject><subject>Asthma - ethnology</subject><subject>Asthma - genetics</subject><subject>Asthma - metabolism</subject><subject>Asthma - physiopathology</subject><subject>Ethnic Groups</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Prostaglandin D2 - genetics</subject><subject>Prostaglandin D2 - metabolism</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Prostaglandin - genetics</subject><subject>Receptors, Prostaglandin - metabolism</subject><subject>Signal Transduction</subject><issn>1323-8930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j81OwzAQhH0A0VJ4BfAJwSHF9jp2cqxafioVIVW9R05sN0FOHWL30LfHiHLakWZm9Q1C95TMGQB7Vs6Zce9dd4hzUmTbxTojBOACTSkwyIoSyARdh_BFCGWylFdoQouSCwZsij623hnsLR5GH6LaO3XQ3QGvHtkTThJ3MeDRNGaIfgw4ObE1eFCx9UN7Cp13fn_6rasQ217doEurXDC35ztDu9eX3fI923y-rZeLTTbknGWskTXPCdW51UbaQiREkKJh2lrGLOEqN9QmQ7NaAwdSk1xyLmhBc254DTP08Pc2QX8fTYhV34XGuARv_DFUoiygFFKk4N05eKx7o6th7Ho1nqr__fADOM1d5A</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Oguma, Tsuyoshi</creator><creator>Asano, Koichiro</creator><creator>Ishizaka, Akitoshi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma</title><author>Oguma, Tsuyoshi ; Asano, Koichiro ; Ishizaka, Akitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p542-2c7b4501d5fde7f86893376c2dff22f04a5e1f7f8d2bd3430b05744618154e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Asthma - ethnology</topic><topic>Asthma - genetics</topic><topic>Asthma - metabolism</topic><topic>Asthma - physiopathology</topic><topic>Ethnic Groups</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Prostaglandin D2 - genetics</topic><topic>Prostaglandin D2 - metabolism</topic><topic>Receptors, Immunologic - genetics</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Prostaglandin - genetics</topic><topic>Receptors, Prostaglandin - metabolism</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oguma, Tsuyoshi</creatorcontrib><creatorcontrib>Asano, Koichiro</creatorcontrib><creatorcontrib>Ishizaka, Akitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Allergology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oguma, Tsuyoshi</au><au>Asano, Koichiro</au><au>Ishizaka, Akitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma</atitle><jtitle>Allergology international</jtitle><addtitle>Allergol Int</addtitle><date>2008-12</date><risdate>2008</risdate><volume>57</volume><issue>4</issue><spage>307</spage><epage>312</epage><pages>307-312</pages><issn>1323-8930</issn><abstract>Prostaglandin D(2) (PGD(2)) is one of the most abundant lipid mediators present in the airways of asthmatics. 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| ispartof | Allergology international, 2008-12, Vol.57 (4), p.307-312 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Asthma - ethnology Asthma - genetics Asthma - metabolism Asthma - physiopathology Ethnic Groups Genetic Predisposition to Disease Humans Linkage Disequilibrium Mice Mice, Knockout Polymorphism, Single Nucleotide Promoter Regions, Genetic Prostaglandin D2 - genetics Prostaglandin D2 - metabolism Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Prostaglandin - genetics Receptors, Prostaglandin - metabolism Signal Transduction |
| title | Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma |
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