Association of the androgen receptor gene (AR) with ADHD and conduct disorder
THE male predominance of externalizing behaviors suggests that the X-linked androgen gene might be involved. Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with externali...
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| Veröffentlicht in: | Neuroreport 1999-05, Vol.10 (7), p.1589-1592 |
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| creator | Comings, David E Chen, Cynthia Wu, Shijuan Muhleman, Donn |
| description | THE male predominance of externalizing behaviors suggests that the X-linked androgen gene might be involved. Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with externalizing behaviors. We examined 302 subjects consisting of Tourette syndrome probands and controls. ANOVA showed a significant association between the AR haplotypes and ADHD (p < 0.0001), conduct disorder (CD; p < 0.017), and oppositional defiant disorder (ODD; p < 0.004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders. |
| doi_str_mv | 10.1097/00001756-199905140-00036 |
| format | Article |
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Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with externalizing behaviors. We examined 302 subjects consisting of Tourette syndrome probands and controls. ANOVA showed a significant association between the AR haplotypes and ADHD (p < 0.0001), conduct disorder (CD; p < 0.017), and oppositional defiant disorder (ODD; p < 0.004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199905140-00036</identifier><identifier>PMID: 10380986</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult and adolescent clinical studies ; Analysis of Variance ; Attention Deficit Disorder with Hyperactivity - genetics ; Biological and medical sciences ; Case-Control Studies ; Conduct Disorder - genetics ; Female ; Genetic Linkage ; Genotype ; Haplotypes ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with externalizing behaviors. We examined 302 subjects consisting of Tourette syndrome probands and controls. ANOVA showed a significant association between the AR haplotypes and ADHD (p < 0.0001), conduct disorder (CD; p < 0.017), and oppositional defiant disorder (ODD; p < 0.004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders.</description><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Conduct Disorder - genetics</subject><subject>Female</subject><subject>Genetic Linkage</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Androgen - genetics</subject><subject>Tourette Syndrome - genetics</subject><subject>X Chromosome</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VFrFDEQB_Agir1Wv4LkoUj7sDq5bLLJ49GqLVQEUfAtzGYnvdW9zTXZ5fDbm3pn64uYl5DhN0n4D2NcwBsBtnkLZYlG6UpYa0GJGqpSkfoJW4i6kZVS5ttTtgCrbFVbrY7Ycc7fC7EgzHN2JEAasEYv2MdVztH3OPVx5DHwaU0cxy7FWxp5Ik_bKSZeDsTPVp_P-a6f1nx1eXV5r7iPYzf7iXd9jqmj9II9CzhkennYT9jX9---XFxVN58-XF-sbipfC60rDORtBwqCBGygbdsagy5_wqVRiLINWnY2LIFUaEgX2OoGwbdLjUCykSfs9f7ebYp3M-XJbfrsaRhwpDhnp62RFpbiv1A0EkoYukCzhz7FnBMFt039BtNPJ8DdZ-7-ZO4eMne_My-trw5vzO2Gur8a9yEXcHoAmD0OIeHo-_zojFGmVoXVe7aLw0Qp_xjmHSW3JhymtfvXyOUv0CSXig</recordid><startdate>19990514</startdate><enddate>19990514</enddate><creator>Comings, David E</creator><creator>Chen, Cynthia</creator><creator>Wu, Shijuan</creator><creator>Muhleman, Donn</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990514</creationdate><title>Association of the androgen receptor gene (AR) with ADHD and conduct disorder</title><author>Comings, David E ; Chen, Cynthia ; Wu, Shijuan ; Muhleman, Donn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4166-afec9d050f30a70bbb4af6038a285aa3bf63d9f20e5f7e6050b67a0cb26a0e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Conduct Disorder - genetics</topic><topic>Female</topic><topic>Genetic Linkage</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Polymorphism, Genetic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptors, Androgen - genetics</topic><topic>Tourette Syndrome - genetics</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Comings, David E</creatorcontrib><creatorcontrib>Chen, Cynthia</creatorcontrib><creatorcontrib>Wu, Shijuan</creatorcontrib><creatorcontrib>Muhleman, Donn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Comings, David E</au><au>Chen, Cynthia</au><au>Wu, Shijuan</au><au>Muhleman, Donn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the androgen receptor gene (AR) with ADHD and conduct disorder</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1999-05-14</date><risdate>1999</risdate><volume>10</volume><issue>7</issue><spage>1589</spage><epage>1592</epage><pages>1589-1592</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>THE male predominance of externalizing behaviors suggests that the X-linked androgen gene might be involved. Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with externalizing behaviors. We examined 302 subjects consisting of Tourette syndrome probands and controls. ANOVA showed a significant association between the AR haplotypes and ADHD (p < 0.0001), conduct disorder (CD; p < 0.017), and oppositional defiant disorder (ODD; p < 0.004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10380986</pmid><doi>10.1097/00001756-199905140-00036</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult and adolescent clinical studies Analysis of Variance Attention Deficit Disorder with Hyperactivity - genetics Biological and medical sciences Case-Control Studies Conduct Disorder - genetics Female Genetic Linkage Genotype Haplotypes Humans Male Medical sciences Middle Aged Miscellaneous Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Androgen - genetics Tourette Syndrome - genetics X Chromosome |
| title | Association of the androgen receptor gene (AR) with ADHD and conduct disorder |
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