Focal pathology in the Edinger-Westphal nucleus explains pupillary hypersensitivity in Alzheimer's disease

Patients who suffer from Alzheimer's disease (AD) and a sub-population of community-dwelling elders show an exaggerated pupillary reaction to dilute tropicamide, a cholinergic antagonist. This finding may serve as an early diagnostic marker of AD. Here we report a likely pathological basis for...

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Veröffentlicht in:	Acta neuropathologica 1999-06, Vol.97 (6), p.557-564
Hauptverfasser:	SCINTO, L. F. M, WU, C. K, FIRLA, K. M, DAFFNER, K. R, SAROFF, D, GEULA, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Biological and medical sciences Brain - pathology Brain - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Edinger-Westphal nucleus Humans Hypersensitivity Immunohistochemistry Medical sciences Neurodegenerative diseases Neurology Oculomotor Nerve - pathology Oculomotor Nerve - physiopathology Pathology Plaques Pupil - physiology Reflex, Pupillary - physiology
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