Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: Behavioral and neurophysiological evidence

Abstract Somatostatin (SST) is a cyclic polypeptide that inhibits the release of a variety of regulatory hormones (e.g. growth hormone, insulin, glucagon, thyrotropin). Moreover, SST is widely distributed within the CNS, acting both as a neurotransmitter and as a neuromodulator of other neurotransmi...

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Veröffentlicht in:	Neuroscience 2008-12, Vol.157 (3), p.666-676
Hauptverfasser:	Engin, E, Stellbrink, J, Treit, D, Dickson, C.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - administration & dosage Antidepressive Agents - administration & dosage anxiety Behavior, Animal - drug effects Bicuculline - pharmacology Biological and medical sciences depression Diazepam - pharmacology Dose-Response Relationship, Drug Electric Stimulation - methods Electroencephalography elevated plus maze Fundamental and applied biological sciences. Psychology hippocampal theta rhythm Hippocampus - drug effects Hippocampus - physiology Injections, Intraventricular - methods Male Maze Learning - drug effects Medical sciences Neurology neuropeptide Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology rat Rats Rats, Sprague-Dawley Somatostatin - administration & dosage Spectrum Analysis Swimming Theta Rhythm - drug effects Vertebrates: nervous system and sense organs
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