Antiviral activity of sandalwood oil against Herpes simplex viruses-1 and -2

Sandalwood oil, the essential oil of Santalum album L., was tested for in vitro antiviral activity against Herpes simplex viruses-1 and -2. It was found that the replication of these viruses was inhibited in the presence of the oil. This effect was dose-dependent and more pronounced against HSV-1. A...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 1999-05, Vol.6 (2), p.119-123
Hauptverfasser:	Benencia, F., Courrèges, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiviral activity Antiviral Agents - pharmacology Cercopithecus aethiops Dose-Response Relationship, Drug Herpes simplex Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - growth & development Herpesvirus 1, Human - physiology Herpesvirus 2, Human - drug effects Herpesvirus 2, Human - growth & development Herpesvirus 2, Human - physiology Microbial Sensitivity Tests Plant Oils - pharmacology sandalwood oil Santalum album L Vero Cells Viral Plaque Assay Virus Replication - drug effects
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Zusammenfassung:	Sandalwood oil, the essential oil of Santalum album L., was tested for in vitro antiviral activity against Herpes simplex viruses-1 and -2. It was found that the replication of these viruses was inhibited in the presence of the oil. This effect was dose-dependent and more pronounced against HSV-1. A slight diminution of the effect was observed at higher multiplicity of infections. The oil was not virucidal and showed no cytotoxicity at the concentrations tested.
ISSN:	0944-7113 1618-095X
DOI:	10.1016/S0944-7113(99)80046-4